SB Jørgensen, JN Nielsen, JB Birk, GS Olsen, B Viollet, … - Diabetes, 2004 - Am Diabetes Assoc The 5'AMP-activated protein kinase (AMPK) is a potential antidiabetic drug target. Here we show
that the pharmacological activation of AMPK by 5-aminoimidazole-1-ß-4-carboxamide ribofuranoside
(AICAR) leads to inactivation of glycogen synthase (GS) and phosphorylation of GS at Ser ... Cited by 63 - Related articles - BL Direct - All 4 versions
D Carling, DG Hardie - Biochimica et biophysica acta, 1989 - ncbi.nlm.nih.gov In addition to acetyl-CoA carboxylase and HMG-CoA reductase, the AMP-activated protein kinase
phosphorylates glycogen synthase, phosphorylase kinase, hormone-sensitive lipase and
casein. A number of other substrates for the cyclic AMP-dependent protein kinase, eg, L- ... Cited by 140 - Related articles - All 3 versions
BR Barnes, S Marklund, TL Steiler, M Walter, G … - Journal of Biological …, 2004 - ASBMB 5′-AMP-activated protein kinase (AMPK) is a metabolic stress sensor present in all
eukaryotes. A dominant missense mutation (R225Q) in pig PRKAG3, encoding the muscle-specific
γ3 isoform, causes a marked increase in glycogen content. To determine the functional ... Cited by 96 - Related articles - BL Direct - All 5 versions
- ►fasebj.org BR Barnes, S Glund, YC Long, G Hjalm, L Andersson, … - The FASEB journal, 2005 - FASEB 5'-AMP-activated protein kinase (AMPK) activity is increased during exercise in an intensity-
and glycogen-dependent manner. We previously reported that a mutation in the AMPK 3 subunit
(Prkag3 225Q ) increases AMPK activity and skeletal muscle glycogen content. ... Cited by 32 - Related articles - All 3 versions
J Mu, E Barton, M Birnbaum - Biochemical Society Transactions, 2003 - bst.portlandpress.com AMP-activated protein kinase (AMPK) is becoming recognized as a critical regulator of energy
metabolism in cells. Using a mouse model in which we specifically blocked AMPK activity in
muscles, we have demonstrated that activation of AMPK is necessary for the effects of 5- ... Cited by 54 - Related articles - Cached - BL Direct - All 9 versions
- ►cell.com G Polekhina, A Gupta, BJW van Denderen, SC Feil, BE … - Structure, 2005 - Elsevier AMP-activated protein kinase (AMPK) coordinates cellular metabolism in response to energy
demand as well as to a variety of stimuli. The AMPK β subunit acts as a scaffold for the α catalytic
and γ regulatory subunits and targets the AMPK heterotrimer to glycogen. We have ... Cited by 41 - Related articles - All 10 versions
ER Hudson, DA Pan, J James, JM Lucocq, SA Hawley, … - Current biology, 2003 - Elsevier The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that is activated by low cellular
energy status and affects a switch away from energy-requiring processes and toward catabolism
[1]. While it is primarily regulated by AMP and ATP, high muscle glycogen has also been ... Cited by 147 - Related articles - All 10 versions
- ►physiology.org BF Holmes, DB Lang, MJ Birnbaum, J Mu … - American Journal of …, 2004 - Am Physiological Soc An acute bout of exercise increases muscle GLUT4 mRNA in mice, and denervation decreases
GLUT4 mRNA. AMP-activated protein kinase (AMPK) activity in skeletal muscle is also increased
by exercise, and GLUT4 mRNA is increased in mouse skeletal muscle after treatment with ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►physiology.org PE Durante, KJ Mustard, SH Park, WW … - American Journal of …, 2002 - Am Physiological Soc The effects of endurance training on the response of muscle AMP-activated protein kinase
(AMPK) and acetyl-CoA carboxylase (ACC) to moderate treadmill exercise were examined. In
red quadriceps, there was a large activation of 2-AMPK and inactivation of ACC in ... Cited by 78 - Related articles - BL Direct - All 4 versions
