IS Harris, I Treskov, MW Rowley, S Heximer, K … - Diabetes, 2004 - Am Diabetes Assoc Diabetic patients develop a cardiomyopathy that consists of ventricular hypertrophy and diastolic
dysfunction. Although the pathogenesis of this condition is poorly understood, previous studies
implicated abnormal G-protein activation. In this work, mice with cardiac overexpression ... Cited by 26 - Related articles - BL Direct - All 6 versions
A Ellen, C Marie - Canadian journal of physiology and …, 2005 - ingentaconnect.com Abstract: Peroxisome proliferator-activated receptor-α (PPARα) regulates the expression of fatty
acid (FA) oxidation genes in liver and heart. Although PPARα ligands increased FA oxidation
in cultured cardiomyocytes, the cardiac effects of chronic PPARα ligand administration in ... Cited by 24 - Related articles - All 7 versions
Y Nishio, A Kanazawa, Y Nagai, H Inagaki … - ANNALS-NEW …, 2004 - interscience.wiley.com Abstract: To clarify the mechanism of abnormalities in mitochondrial expression and function
in diabetic rat heart, we have studied the transcriptional activities of mitochondrial DNA using
isolated intact mitochondria from the heart of either diabetic or control rats. The ... Cited by 20 - Related articles - BL Direct - All 5 versions
SY Park, YR Cho, BN Finck, HJ Kim, T Higashimori, EG … - Diabetes, 2005 - Am Diabetes Assoc Diabetic heart failure may be causally associated with alterations in cardiac energy metabolism
and insulin resistance. Mice with heart-specific overexpression of peroxisome proliferator–activated
receptor (PPAR)α showed a metabolic and cardiomyopathic phenotype similar to the ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org I Luptak, JA Balschi, Y Xing, TC Leone, DP Kelly, R … - Circulation, 2005 - Am Heart Assoc Methods and Results— We assessed contractile function and substrate utilization using 13 C
nuclear magnetic resonance spectroscopy and high-energy phosphate metabolism using 31
P nuclear magnetic resonance spectroscopy in perfused hearts isolated from genetically ... Cited by 43 - Related articles - All 7 versions
[CITATION] Up-regulation of the fatty acid oxidation (FAO) pathway does not exacerbate heart …
WC Stanley, EE Morgan, MP Chandler, BD Hoit - Cardiovascular Journal of South Africa, 2004 Cited by 3 - Related articles
- ►physiology.org M Panagia, GF Gibbons, GK Radda, K … - American Journal of …, 2005 - Am Physiological Soc The transcription of key metabolic regulatory enzymes in the heart is altered in the diabetic
state, yet little is known of the underlying mechanisms. The aim of this study was to investigate
the role of peroxisome proliferator-activated receptor- (PPAR- ) in modulating cardiac ... Cited by 34 - Related articles - All 5 versions
- ►physiology.org N Sambandam, D Morabito, C Wagg, BN … - American Journal of …, 2006 - Am Physiological Soc High fatty acid oxidation (FAO) rates contribute to ischemia-reperfusion injury of the
myocardium. Because peroxisome proliferator-activated receptor (PPAR) regulates transcription
of several FAO enzymes in the heart, we examined the response of mice with cardiac- ... Cited by 38 - Related articles - BL Direct - All 2 versions
WS Cook, AV Yeldandi, MS Rao, T Hashimoto, JK … - … and Biophysical Research …, 2000 - Elsevier The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that transcriptionally
regulates mitochondrial and peroxisomal fatty acid β-oxidation enzymes in the liver. Ligands
include synthetic peroxisome proliferators and some fatty acids. PPARα activation leads ... Cited by 41 - Related articles - BL Direct - All 7 versions
AECM Simpson, WJ Brammar, MK Pratten, CR … - Biochemical …, 1995 - Elsevier Lactating mothers of 7.5-day neonatal rats were injected intraperitoneally with 500 mg kg −1
clofibrate for 3 consecutive days at 24-hour intervals; 24 hours after the final injection, the maternal
cytochrome P450 4A (CYP4A) mRNA levels had risen 14- and 2.5-fold above the ... Cited by 8 - Related articles - BL Direct - All 4 versions
