Y Lu, PL Herrera, Y Guo, D Sun, Z Tang, D … - Diabetes, 2004 - Am Diabetes Assoc The dogma that IGF-I stimulates pancreatic islet growth has been challenged by
combinational targeting of IGF or IGF-IR (IGF receptor) genes as well as
β-cell–specific IGF-IR gene deficiency, which caused no defect in islet ... Cited by 40 - Related articles - BL Direct - All 4 versions
R Yu, S Yakar, YL Liu, Y Lu, D LeRoith, D Miao … - Molecular and cellular endocrinology, 2003 - Elsevier Liver-specific IGF-I gene deficient (LID) mice exhibit pancreatic islet
hyperplasia and insulin resistance. To clarify their causal relationship, we
studied age-dependent changes in these two aspects and the response to ... Cited by 16 - Related articles - All 7 versions
- ►nih.gov S Xuan, T Kitamura, J Nakae, K Politi, Y Kido, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Defective insulin secretion is a feature of type 2 diabetes that results from
inadequate compensatory increase of β cell mass and impaired glucose-dependent
insulin release. β cell proliferation and secretion are thought to be ... Cited by 115 - Related articles - BL Direct - All 11 versions
RN Kulkarni - Reviews in Endocrine & Metabolic Disorders, 2005 - Springer Page 1. Reviews in Endocrine & Metabolic Disorders 2005;6:199–210 C 2005 Springer
Science + Business Media, Inc. Manufactured in The Netherlands. ... Cited by 34 - Related articles - BL Direct - All 3 versions
- ►nih.gov M George, E Ayuso, A Casellas, C Costa, JC … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Patients with type 1 diabetes are identified after the onset of the disease,
when β cell destruction is almost complete. β cell regeneration from islet
cell precursors might reverse this disease, but factors that can induce β ... Cited by 93 - Related articles - BL Direct - All 7 versions
- ►nih.gov JC Devedjian, M George, A Casellas, A Pujol, J … - Journal of Clinical Investigation, 2000 - Am Soc Clin Investig During embryonic development, insulin-like growth factor-II (IGF-II)
participates in the regulation of islet growth and differentiation. We generated
transgenic mice (C57BL6/SJL) expressing IGF-II in β cells under control of ... Cited by 85 - Related articles - All 7 versions
- ►physiology.org Y Lu, A Ponton, H Okamoto, S Takasawa, PL … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc We have recently reported that Pdx1-Cre-mediated whole pancreas inactivation of
IGF-I gene [in pancreatic-specific IGF-I gene-deficient (PID) mice] results in
increased -cell mass and significant protection against both type 1 and ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►endojournals.org R Robitaille, J Dusseault, N Henley, L … - Endocrinology, 2003 - Endocrine Soc TWENTY-SEVEN YEARS of sustained work have been required to bring the concept of
islet transplantation as proposed by Lacy and Kostianovsky (1), to successful
clinical application, as recently reported by the Edmonton group (2, 3). ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►endojournals.org B Duvillie, C Currie, T Chrones, D Bucchini, J … - Endocrinology, 2002 - Endocrine Soc INSULIN IS A major anabolic hormone for the growth and development of the
mammalian embryo and fetus, and its production by the pancreatic ß-cells within
the islets of Langerhans must be closely entrained to the demands of the ... Cited by 43 - Related articles - BL Direct - All 3 versions
GA Adams, X Wang, LK Lee, CE Piercy, EJ … - Surgery, 1994 - ncbi.nlm.nih.gov BACKGROUND. Fetal pancreas (FP) has the capacity for exuberant proliferation and
engrafts in the safe, accessible intramuscular site. These characteristics make
FP transplantation an attractive approach to the treatment of diabetes ... Cited by 13 - Related articles - BL Direct - All 2 versions
