- ►diabetesjournals.org MS Remedi, J Koster… - Diabetes, 2004 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) control electrical activity in β-cells and therefore
are key players in excitation-secretion coupling. Partial suppression of β-cell K ATP channels
in transgenic (AAA) mice causes hypersecretion of insulin and enhanced glucose ... Cited by 17 - Related articles - BL Direct - All 5 versions
JC Koster, MS Remedi, TP Flagg, JD … - Proceedings of the …, 2002 - National Acad Sciences ATP-sensitive K + (K ATP ) channels couple cell metabolism to electrical activity. To probe the
role of K ATP in glucose-induced insulin secretion, we have generated transgenic mice expressing
a dominant-negative, GFP-tagged K ATP channel subunit in which residues 132–134 ... Cited by 25 - Related articles - BL Direct - All 9 versions
- ►physiology.org NM Doliba, W Qin, MZ Vatamaniuk, C Li, … - American Journal of …, 2004 - Am Physiological Soc Inhibition of ATP-sensitive K + (K ATP ) channels by an increase in the ATP/ADP ratio and the
resultant membrane depolarization are considered essential in the process leading to insulin
release (IR) from pancreatic -cells stimulated by glucose. It is therefore surprising that ... Cited by 37 - Related articles - BL Direct - All 6 versions
P Filipponi, F Gregorio, M Marcelli, S … - Diabetes research and …, 1989 - ncbi.nlm.nih.gov We previously reported that sulfonylurea treatment reduces insulin (IRI), glucagon (IRG) and
somatostatin (SRIF) release following metabolic stimuli from the isolated perfused pancreas
of normal rats and that a reduction in IRI, IRG and SRIF pancreatic content was also ... Cited by 3 - Related articles
T Ikeda, K Fujiyama, T Hoshino, T Takeuchi, H … - Experimental and …, 1990 - ncbi.nlm.nih.gov To investigate the effects of insulin and sulfonylurea drug administration on islet A and B-cell
functions, insulin and glucagon response was studied in normal rats treated with insulin (4
U/day subcutaneously) or glibenclamide (0.03 mg/kg intraperitoneally) for 8 weeks. In ... Cited by 3 - Related articles
- ►physiology.org T Miki, K Minami, L Zhang, M Morita, T … - American Journal of …, 2002 - Am Physiological Soc ATP-sensitive potassium (K ATP ) channels are known to be critical in the control of both insulin
and glucagon secretion, the major hormones in the maintenance of glucose homeostasis. The
involvement of K ATP channels in glucose uptake in the target tissues of insulin, however, ... Cited by 44 - Related articles - BL Direct - All 4 versions
MS Remedi, JV Rocheleau, A Tong, BL Patton, ML … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis ATP-sensitive K + (K ATP ) channels couple glucose metabolism to
insulin secretion in pancreatic beta cells. In humans, loss-of-function mutations of beta cell K
ATP subunits (SUR1, encoded by the gene ABCC8, or Kir6.2, encoded by the gene ... Cited by 13 - Related articles - BL Direct - All 4 versions
MJ MacDonald, A Kowluru - Molecular and Cellular Biochemistry, 1985 - Springer Pancreatic islet cytosol contains a calcium-calmodulin dependent protein kinase that can mediate
the phos- phorylation of an endogenous protein that has an Mr of 57 000, as well as exogenous
muscle pyruvate kinase (subunit Mr, 57000). EGTA and trifluoperazine decreased the ... Cited by 7 - Related articles - All 2 versions
- ►jbc.org A Szollosi, M Nenquin, JC Henquin - Journal of Biological Chemistry, 2007 - ASBMB A current model ascribes glucose-induced insulin secretion to the interaction of a triggering pathway
(K ATP channel-dependent Ca 2+ influx and rise in cytosolic [Ca 2+ ] c ) and an amplifying pathway
(K ATP channel-independent augmentation of secretion without further increase of [Ca 2+ ... Cited by 14 - Related articles - All 6 versions
JV Rocheleau, MS Remedi, B Granada, WS Head, JC … - biology.plosjournals.org The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged from a common
ancestor roughly 100 million years ago and yet are almost indistinguishable by eye. They have
the same chromosome number and genome sizes, and they occupy the same ecological ... Cited by 22 - Related articles - Cached - BL Direct - All 13 versions
