- ►diabetesjournals.org LZ Cao, DQ Tang, ME Horb, SW Li, LJ Yang - Diabetes, 2004 - Am Diabetes Assoc Pdx1 has been shown to convert hepatocytes into both exocrine and endocrine pancreatic cells
in mice, but it fails to selectively convert hepatocytes into pure insulin-producing cells (IPCs).
The molecular mechanisms underlying the transdifferentiation remain unclear. In this ... Cited by 65 - Related articles - BL Direct - All 6 versions
J Imai, H Katagiri, T Yamada, Y Ishigaki, T Ogihara, … - … and Biophysical Research …, 2005 - Elsevier To generate insulin-producing cells in the liver, recombinant adenovirus containing a constitutively
active mutant of PDX1 (PDX1-VP16), designed to activate target genes without the need for protein
partners, was prepared and administered intravenously to streptozotocin (STZ)-treated ... Cited by 32 - Related articles - All 4 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T Matsuoka, M … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients
worldwide is increasing. The reduction of insulin biosynthesis in pancreatic β-cells is closely
associated with the onset and progression of diabetes, and thus it is important to search ... Cited by 54 - Related articles - All 6 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, Y … - … and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in inducing differentiation
into insulin-producing cells has been demonstrated in some cells and tissues. In order to carry
out efficient screening of somatic tissues and cells that can transdifferentiate into ... Cited by 46 - Related articles - All 6 versions
DQ Tang, LZ Cao, BR Burkhardt, CQ Xia, SA Litherland … - Diabetes, 2004 - Am Diabetes Assoc Efforts toward routine islet cell transplantation as a means for reversing type 1 diabetes have
been hampered by islet availability as well as allograft rejection. In vitro transdifferentiation of
mouse bone marrow (BM)-derived stem (mBMDS) cells into insulin-producing cells could ... Cited by 214 - Related articles - BL Direct - All 7 versions
M Zalzman, L Anker-Kitai, S Efrat - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet insulin-producing
β-cells. Insulin administration does not prevent long-term complications of the disease, as the
optimal insulin dosage is difficult to adjust. Replacement of the damaged cells with ... Cited by 71 - Related articles - BL Direct - All 5 versions
Y Fujita, AT Cheung, TJ Kieffer - Pediatric Diabetes, 2004 - pt.wkhealth.com The gut contains one of the largest stem cell populations in the body, yet has been largely overlooked
as a source of potentially therapeutic cells. The stem cells reside in the crypts located at the base
of the protruding villi, reproduce themselves, and repopulate the gut lining as ... Cited by 23 - Related articles - BL Direct - All 4 versions
WC Li, ME Horb, D Tosh, JMW Slack - Mechanisms of development, 2005 - Elsevier We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic
cells following introduction of an activated version of the pancreatic transcription factor Pdx1
(XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic ... Cited by 54 - Related articles - All 6 versions
DQ Tang, S Lu, YP Sun, E Rodrigues, W Chou, … - Laboratory …, 2006 - pathology.ufl.edu Adenovirus-mediated transient expression of the pancreatic duodenal homeobox transcription
factor Pdx1 in mouse liver activates pancreatic endocrine and exocrine genes, the latter reportedly
resulting in severe hepatitis. Expression of a super-active form of Pdx1 or Pdx1-VP16 ... Cited by 27 - Related articles - View as HTML - BL Direct - All 6 versions
I Ber, K Shternhall, S Perl, Z Ohanuna, I Goldberg, I … - Journal of Biological …, 2003 - ASBMB Pancreatic and duodenal homeobox gene-1 (PDX-1) regulates pancreas development during
embryogenesis, whereas in the adult it controls β-cell function. Here we analyze whether
PDX-1 functions as a pancreatic differentiation factor and a bona fide master regulator ... Cited by 106 - Related articles - BL Direct - All 4 versions
