- ►diabetesjournals.org K Almind, CR Kahn - Diabetes, 2004 - Am Diabetes Assoc Diet-induced obesity is the primary determinant of the current epidemic of
diabetes. We have explored the role of genetics in this phenomenon, using
C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 × 129)F2 mice on a ... Cited by 52 - Related articles - BL Direct - All 6 versions
K Almind, RN Kulkarni, SM Lannon, CR Kahn - Diabetes, 2003 - Am Diabetes Assoc Mice double heterozygous (DH) for deletion of insulin receptor and insulin
receptor substrate-1 are lean, insulin resistant, and have a phenotype that
strongly depends on the genetic background of the mouse. On the C57BL/6 ... Cited by 30 - Related articles - BL Direct - All 4 versions
T Kayo, H Fujita, J Nozaki… - Comparative medicine, 2000 - ncbi.nlm.nih.gov BACKGROUND AND PURPOSE: Our objective was to map the genes responsible for poor
glucose tolerance in a C57BL/6 (B6) mouse model, which provides a human model of
non-insulin-dependent diabetes mellitus. Insulin secretion was found to be ... Cited by 16 - Related articles - BL Direct
C Colombo, M Haluzik, JJ Cutson, KR Dietz, … - Journal of Biological Chemistry, 2003 - ASBMB The metabolic phenotype of the A-ZIP/F-1 (AZIP) lipoatrophic mouse is different
depending on its genetic background. On both the FVB/N (FVB) and C57BL/6J (B6)
backgrounds, AZIP mice have a similarly severe lack of white adipose tissue ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Rossmeisl, JS Rim, RA Koza, LP Kozak - Diabetes, 2003 - Am Diabetes Assoc C57BL/6J (B6) and AKR/J (AKR) inbred strains of mice develop a comparable degree
of obesity when fed a high-fat diet. However, although obese B6 mice are more
glucose intolerant, obese AKR mice are more insulin resistant. To ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►endojournals.org HJ Goren, RN Kulkarni, CR Kahn - Endocrinology, 2004 - Endocrine Soc Transgenic mice phenotypes generally depend on the background strains used in
their creation. To examine the effects of genetic background on insulin
signaling, we analyzed glucose homeostasis in four inbred strains of mice ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►nih.gov DR Reed, X Li, AH McDaniel, K Lu, S Li, MG … - Mammalian Genome, 2003 - Springer Page 1. Loci on Chromosomes 2, 4, 9, and 16 for body weight, body length, and
adiposity identified in a genome scan of an F 2 intercross ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►physiology.org [PDF] GB Collin, TP Maddatu, S Sen, JK Naggert - Physiological Genomics, 2005 - Am Physiological Soc Page 1. PG-00208-2003.R2 Genetic modifiers interact with Cpefat to affect
body weight, adiposity, and hyperglycemia Gayle B. Collin1 ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►physiology.org B Ahren, G Pacini - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc This study evaluated the relative contribution of insulin-dependent mechanisms
vs. mechanisms independent on dynamic insulin for glucose intolerance induced by
high-fat diet. C57BL/6J mice underwent a frequently sampled intravenous ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RN Kulkarni, K Almind, HJ Goren, JN Winnay, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is a complex disease in which genetic and environmental factors
interact to produce alterations in insulin action and insulin secretion, leading
to hyperglycemia. To evaluate the influence of genetic background on ... Cited by 64 - Related articles - BL Direct - All 8 versions
