- ►diabetesjournals.org SK Das, W Chu, Z Zhang, SJ Hasstedt, SC Elbein - Diabetes, 2004 - Am Diabetes Assoc Genome-wide scans in multiple populations have identified chromosome 1q21-q24 as one susceptibility
region for type 2 diabetes. To map the susceptibility genes, we first placed a dense single nucleotide
polymorphism (SNP) map across the linked region. We identified two SNPs that showed ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Fu, CM Damcott, M Sabra, TI Pollin, SH Ott, J Wang, … - Diabetes, 2004 - Am Diabetes Assoc Calsequestrin (CASQ)1 is involved in intracellular storage and release of calcium, a process
that has been shown to mediate glucose transport in muscle. Its gene, CASQ1, is encoded on
chromosome 1q21, a region that has been linked to type 2 diabetes in the Amish and ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org SK Das, WS Chu, TC Hale, X Wang, RL Craig, H Wang, … - Diabetes, 2006 - Am Diabetes Assoc Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across populations. In
an initial 50-kb marker map (580 markers) across the linked region, one of the two strongest
associations observed in Utah Caucasians was at marker rs1503814 (P < 0.00001 in ... Cited by 12 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org WS Chu, SK Das, H Wang, JC Chan, P Deloukas, P … - Diabetes, 2007 - Am Diabetes Assoc Activating transcription factor 6 (ATF6) is located within the region of linkage to type 2 diabetes
on chromosome 1q21-q23 and is a key activator of the endoplasmic reticulum stress
response. We evaluated 78 single nucleotide polymorphisms (SNPs) spanning >213 kb ... Cited by 8 - Related articles - BL Direct - All 12 versions
[CITATION] Meta-analysis of 3,000 single nucleotide polymorphisms from chromosome 1q in …
- ►diabetesjournals.org H Wang, W Chu, SK Das, Q Ren, SJ Hasstedt, SC … - Diabetes, 2002 - Am Diabetes Assoc Pyruvate kinase is a key glycolytic enzyme. Isoforms that are expressed in the red cell, liver, pancreatic
β-cells, small intestine, and proximal renal tubule are encoded by the 12 exons of the PKLR
gene, which maps to chromosome 1q23. We hypothesized that common variants of the ... Cited by 27 - Related articles - BL Direct - All 4 versions
SK Das, SJ Hasstedt, Z Zhang, SC Elbein - Diabetes, 2004 - Am Diabetes Assoc We have identified a region on chromosome 1q21-q24 that was significantly linked to type 2
diabetes in multiplex families of Northern European ancestry and also in Pima Indians, Amish
families, and families from France and England. We sought to narrow and map this locus ... Cited by 43 - Related articles - BL Direct - All 6 versions
F Howarth, L Glover, K Culligan, M Qureshi, K … - Pflügers Archiv European …, 2002 - Springer Cytosolic calcium (Ca 2+ ) levels play a central role in the physiological regulation of
excitation–contraction cou- pling and relaxation in muscle fibres [1, 2, 3]. Within the sarcoplasmic
reticulum (SR) Ca 2+ -handling apparatus, the medium-affinity high-capacity Ca 2+ ... Cited by 10 - Related articles - BL Direct - All 3 versions
SK Das, SC Elbein - Current Diabetes Reports, 2007 - Springer The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of
type 2 diabetes mel- litus to the chromosome 1q21-25 region in at least eight independent
studies. More than 26 candidate genes have already been evaluated, but to date none ... Cited by 14 - Related articles - BL Direct - All 2 versions
