JC Florez, M Sjögren, N Burtt, M Orho-Melander, S … - Diabetes, 2004 - Am Diabetes Assoc The insulin receptor substrate (IRS)-1 is an important component of the insulin signal transduction
cascade. Several reports suggest that a Gly→Arg change in codon 972 is associated with type
2 diabetes and related traits, and a recent meta-analysis reported a modest but nominally ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org E Zeggini, J Parkinson, S Halford, KR Owen, TM … - Diabetes, 2004 - Am Diabetes Assoc The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate
for a contributory role in type 2 diabetes susceptibility. Indeed, functional studies have implicated
the G971R variant, and a recent meta-analysis of 27 association studies suggested that ... Cited by 17 - Related articles - BL Direct - All 5 versions
RM Van Dam, B Hoebee, JC Seidell, MM … - Diabetic …, 2004 - interscience.wiley.com Aims The insulin receptor substrate-1 (IRS-1) gene is among the most frequently studied candidate
genes for Type 2 diabetes, but findings have been inconsistent. This may have been due to generally
small study sizes, or to interaction with body fatness as suggested by studies of insulin ... Cited by 21 - Related articles - BL Direct - All 4 versions
A Jellema, MPA Zeegers, EJM Feskens, PC Dagnelie, … - Diabetologia, 2003 - Springer Aims/hypothesis. Several case-control studies have ex- amined the association between the
Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and results
could therefore be conflict- ing. Methods. We systematically reviewed the literature by ... Cited by 75 - Related articles - BL Direct - All 5 versions
JC Florez, CM Agapakis, NP Burtt, M Sun, P Almgren, L … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin
signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling
molecules. Due to its chromosomal location under a chromosome 20 linkage peak and ... Cited by 25 - Related articles - All 8 versions
- ►diabetesjournals.org W Winckler, RR Graham, PIW de Bakker, M Sun, P … - Diabetes, 2005 - Am Diabetes Assoc Two recent publications reported association of common polymorphisms in the P2 promoter
of hepatocyte nuclear factor 4α (HNF4α) (the MODY1 gene) with risk for type 2 diabetes. We
attempted to reproduce this putative association by genotyping 11 single nucleotide ... Cited by 59 - Related articles - All 8 versions
- ►diabetesjournals.org JC Florez, N Burtt, PIW de Bakker, P Almgren, T Tuomi, … - Diabetes, 2004 - Am Diabetes Assoc The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its associated islet
ATP-sensitive potassium channel (Kir6.2; encoded by KCNJ11) are adjacent to one another
on human chromosome 11. Multiple studies have reported association of the E23K ... Cited by 148 - Related articles - BL Direct - All 7 versions
JC Florez, M Sjögren, CM Agapakis, NP Burtt, P … - Diabetologia, 2007 - Springer Page 1. ARTICLE Association testing of common variants in the insulin receptor substrate-1 gene
(IRS1) with type 2 diabetes JC Florez & M. Sjögren & CM Agapakis & NP Burtt & P. Almgren &
U. Lindblad & G. Berglund & T. Tuomi & D. Gaudet & MJ Daly & KG Ardlie & ... Cited by 3 - Related articles - BL Direct - All 4 versions
K Shimokawa, H Kadowaki, H Sakura, S Otabe, R … - … and biophysical research …, 1994 - fao.org AGRIS record. Record number, US9515925. Titles, Molecular scanning of the glycogen
synthase and insulin receptor substrate-1 genes in Japanese subjects with
non-insulin-dependent diabetes mellitus. Personal Authors, Shimokawa ... Cited by 30 - Related articles - Cached - BL Direct - All 3 versions
