- ►diabetesjournals.org N Deruytter, O Boulard, HJ Garchon - Diabetes, 2004 - Am Diabetes Assoc Major histocompatibility complex (MHC) plays a largely predominant role in the
genetic predisposition to type 1 diabetes, in both humans and rodents. While
class II loci have long been recognized as essential, they do not fully ... Cited by 16 - Related articles - BL Direct - All 5 versions
CH Grimm*, UC Rogner, P Avner - Autoimmunity, 2003 - informahealthcare.com Three type 1 diabetes associated regions on distal mouse chromosome 6 have
recently been defined by the construction and analysis of a series of congenic
strains, carrying C3H/HeJ genomic material on a NOD/Lt genetic background. ... Cited by 6 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org UC Rogner, F Lepault, MC Gagnerault, D … - Diabetes, 2006 - Am Diabetes Assoc The genetic locus Idd6 confers susceptibility to the spontaneous development of
type 1 diabetes in the NOD mouse. Our studies on disease resistance of the
congenic mouse strain NOD.C3H 6.VIII showed that Idd6 influences T-cell ... Cited by 10 - Related articles - BL Direct - All 7 versions
ML Bergman, C Penha-Goncalves, K Lejon, … - Diabetologia, 2001 - Springer Non-obese diabetic (NOD) mice spontaneously de- velop autoimmune diabetes, a
disease that closely re- sembles Type I (insulin-dependent) diabetes mellitus in
humans [1]. This T-cell-dependent autoimmune disease is multifactorial and ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►tokushima-u.ac.jp [PDF] S Takeshita, M Moritani, K Kunika, H Inoue, M … - Mammalian Genome, 2006 - Springer Abstract To identify novel genetic modifiers of type 2 dia- betes (T2D), we
performed quantitative trait loci (QTL) analysis on F 2 progeny of
hypoinsulinemic diabetic Akita mice, heterozygous for the Ins2 gene ... Cited by 8 - Related articles - BL Direct - All 5 versions
ML Bergman, N Duarte, S Campino, M … - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and
polygenic disease. The NOD-derived genetic factors that contribute to type 1
diabetes are named Idd (insulin-dependent diabetes) loci. To date, the ... Cited by 17 - Related articles - BL Direct - All 4 versions
PA Lyons - Current opinion in immunology, 2002 - Elsevier The identification of the genetic variants that confer susceptibility to common
autoimmune diseases, such as type 1 diabetes (T1D) and systemic lupus
erythematosus (SLE), will provide significant insight into their ... Cited by 12 - Related articles - All 5 versions
SE Eckenrode, Q Ruan, P Yang, W Zheng, RA … - DIABETES-NEW YORK-, 2004 - Am Diabetes Assoc T ype 1 diabetes is a disease manifested when the insulin-producing pancreatic
-cells are de- stroyed by the immune system. Studies using the NOD mouse model,
which spontaneously devel- ops type 1 diabetes, have shown that both B- and ... Cited by 14 - Related articles - BL Direct - All 4 versions
H Hashimoto, T Arai, A Takeguchi, K Hioki, Y … - Comparative medicine, 2006 - aalas.org Although type 2 diabetes mellitus (DM) is usually an adult- onset disease, it is
becoming common in young people.47,49 At the current increasing rate of onset,
it will be one of the world's most common diseases in a few decades and ... Cited by 4 - Related articles - View as HTML - BL Direct - All 4 versions
CC Ducummon, T Berger - Zygote, 2006 - Cambridge Univ Press The acrosome reaction is a fundamental event in the biology of the sperm and is
a prerequisite to fertilization of the egg. Members of the Rho family of GTPases
and their effectors are present in the cytoplasm and/or plasma membrane ... Cited by 4 - Related articles - BL Direct - All 3 versions
