YH Hamid, SA Urhammer, DP Jensen, C … - Diabetes, 2004 - Am Diabetes Assoc Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology
of various human diseases such as type 2 diabetes and obesity. IL-6 signals via
a heterodimeric receptor complex consisting of a soluble IL-6 -subunit ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Wang, Z Zhang, W Chu, T Hale, JJ Cooper, … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc IL-6 levels and polymorphisms have been implicated in type 2 diabetes mellitus
(T2DM) and insulin resistance. The IL-6 receptor (IL-6R) comprises two subunits,
IL-6R and gp130, of which IL-6R confers specificity to IL-6 action and is ... Cited by 28 - Related articles - All 5 versions
JK Wolford, PB Colligan, JD Gruber, C … - Molecular Genetics and Metabolism, 2003 - Elsevier Circulating levels of the cytokine interleukin 6 (IL-6) are elevated in obesity,
correlate with body mass index (BMI), and predict the development of type 2
diabetes mellitus (T2DM). A promoter polymorphism in the IL6 gene is ... Cited by 44 - Related articles - All 3 versions
E Esteve, G Villuendas, J Mallolas, J … - CLINICAL ENDOCRINOLOGY-OXFORD-, 2006 - interscience.wiley.com Objective Low-grade inflammation has been related to obesity, insulin resistance
and the metabolic syndrome. The Asp358Ala variant and the CA-repeat polymorphism
in the interleukin-6 receptor (IL-6R) gene have been reported to be ... Cited by 16 - Related articles - BL Direct - All 4 versions
HF Escobar-Morreale, RM Calvo, G Villuendas, … - Obesity, 2003 - nature.com Results: A microsatellite CA-repeat polymorphism in the IL6R- locus was
associated with obesity. The frequency of the common 149-bp allele was markedly
increased in obese women compared with controls when considering patients ... Cited by 46 - Related articles - BL Direct - All 5 versions
JC Galicia, H Tai, Y Komatsu, Y Shimada, K … - Genes and Immunity, 2004 - nature.com We have investigated the association of the recently identified IL6R
polymorphisms with the serum levels of soluble IL-6 receptor (sIL-6R). sIL-6R is
generated by shedding of the membrane-bound receptor (IL-6R ) or ... Cited by 24 - Related articles - BL Direct - All 2 versions
LH Kim, HS Lee, YJ Kim, JH Jung, JY Kim, BL … - Human Mutation, 2003 - interscience.wiley.com The human interleukin-6 receptor (IL6R) is responsible for signal transduction
of IL6 that might have associations with immune diseases and various infectious
diseases. We have sequenced all 10 exons including the putative splicing ... Cited by 16 - Related articles - BL Direct - All 2 versions
C Huth, IM Heid, C Vollmert, C Gieger, H … - Diabetes, 2006 - ncbi.nlm.nih.gov Several lines of evidence indicate a causal role of the cytokine interleukin
(IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms
in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and ... Cited by 25 - Related articles - BL Direct - All 5 versions
MLC Leite, A Nicolosi, S Cristina, WA Hauser, … - European journal of clinical nutrition, 2003 - nature.com † Contributors: AN designed the protocol, supervised the execution of the
study and collaborated to write the manuscript. SC was the project director. WAH
designed the protocol and directed the training of the field staff. PP ... Cited by 11 - Related articles - BL Direct - All 3 versions
[CITATION] Novel T2DM locus on chromosome 4 and confirmation of chromosome 1q21 T2DM linkage in …
