- ►diabetesjournals.org LJ Ma, SL Mao, KL Taylor, T Kanjanabuch, YF Guan, … - Diabetes, 2004 - Am Diabetes Assoc Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only thrombosis and
fibrosis but also to obesity and insulin resistance. Increased PAI-1 levels have been presumed to be
consequent to obesity. We ... Cited by 174 - Related articles - BL Direct - All 4 versions
- ►fasebj.org [PDF] K Schäfer, K Fujisawa, S Konstantinides, DJ Loskutoff - The FASEB Journal, 2001 - FASEB The FASEB Journal express article 10.1096/fj.00-0750fje. Published online June 27, 2001. ...
Disruption of the plasminogen activator inhibitor-1 gene ... Katrin Schäfer*, Kazuhiku Fujisawa
† , Stavros Konstantinides*, and ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org HR Lijnen, E Maquoi, P Morange, G Voros, B … - … , and vascular biology, 2003 - Am Heart Assoc Methods and Results— Transgenic (Tg) mice overexpressing murine PAI-1 under control of the
adipocyte promoter aP2 and wild-type (WT) controls were kept on standard food (SFD) or on high-fat
diet (HFD) for 15 weeks. The body ... Cited by 76 - Related articles - BL Direct - All 13 versions
- ►ahajournals.org PE Morange, HR Lijnen, MC Alessi, F Kopp, D … - … , and vascular biology, 2000 - Am Heart Assoc Abstract—An increased plasma plasminogen activator inhibitor-1 (PAI-1) level is a risk factor for
myocardial infarction, particularly when associated with visceral obesity. Although the link between
PAI-1 and obesity is well ... Cited by 83 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org DL Crandall, EM Quinet, S El Ayachi, AL … - … , and vascular biology, 2006 - Am Heart Assoc Methods and Results— In human preadipocyte cultures, PAI-039 inhibited both basal and
glucose-stimulated increases in active PAI-1 antigen, yet had no effect on PAI-1 mRNA, suggesting a
direct inactivation of PAI-1. ... Cited by 27 - Related articles - All 9 versions
- ►physiology.org X Liang, T Kanjanabuch, SL Mao, CM Hao … - American Journal of …, 2006 - Am Physiological Soc Increased plasminogen activator inhibitor-1 (PAI-1) is linked to obesity and insulin resistance.
However, the functional role of PAI-1 in adipocytes is unknown. This study was designed to
investigate effects and underlying ... Cited by 45 - Related articles - BL Direct - All 6 versions
R Lopez-Alemany, JM Redondo, Y … - European Journal of …, 2003 - interscience.wiley.com Functional cooperation between integrins and growth factor receptors has been reported for several
systems, one of which is the modulation of insulin signaling by αvβ3 integrin. Plasminogen
activator inhibitor type-1 (PAI-1), ... Cited by 40 - Related articles - BL Direct - All 4 versions
HR Lijnen, MC Alessi, B Van Hoef, D … - … of Thrombosis and …, 2005 - interscience.wiley.com Summary. Objectives: To investigate the role of plasminogen activator inhibitor-1 (PAI-1) in adipose
tissue development and insulin metabolism. Methods: Aged male wild-type (WT) or transgenic mice with
adipose tissue overexpression of ... Cited by 32 - Related articles - All 4 versions
HR Lijnen - Thromb haemost, 2005 - 万方数据资源系统 Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (t-PA)
and urokinase-type (u-PA) plasminogen activator. Recent studies in murine models have yielded
apparently conflicting data on a ... Cited by 18 - Related articles - All 6 versions
BD Taeye, LH Smith, DE Vaughan - Current Opinion in Pharmacology, 2005 - Elsevier A classical perspective of cardiovascular risk does not adequately account for all of the
cardiovascular events associated with obesity and diabetes. The combination of hypertriglyceridemia,
glucose intolerance and ... Cited by 66 - Related articles - All 2 versions
