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Scholar Results 1 - 10 of about 101 related to Pérez: Leptin impairs insulin signaling in rat adipocytes. (0.10 sec) 

Leptin impairs insulin signaling in rat adipocytes

- diabetesjournals.org
C Pérez, C Fernández-Galaz, T Fernández- … - Diabetes, 2004 - Am Diabetes Assoc
Leptin modulates glucose homeostasis by acting as an insulin-sensitizing factor
in most insulin target tissues. Nevertheless, insulin-dependent glucose uptake
in white adipose tissue decreases after in vivo treatment with leptin. ...
Cited by 49 - Related articles - BL Direct - All 6 versions

[PDF] Resistencia a la insulina durante el envejecimiento:¿ un proceso mediado por leptina?


JM Carrascosa, FC Molecular - portal.uam.es
Page 1. Resistencia a la insulina durante el envejecimiento: ¿un proceso
mediado por leptina? José Mª Carrascosa Centro de Biología ...
Related articles - View as HTML

Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats

- uam.es [PDF] 
C Fernandez-Galaz, T Fernandez-Agullo, C … - Diabetologia, 2002 - Springer
Aims/hypothesis. Ageing is associated with insulin and leptin resistance in
mammals. These alterations might be caused by the increased adiposity associated
with ageing, by ageing alone or both. We studied whether leptin resistance ...
Cited by 53 - Related articles - BL Direct - All 5 versions

High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose …

- endojournals.org
G Sweeney, J Keen, R Somwar, D Konrad, R … - Endocrinology, 2001 - Endocrine Soc
Obesity is a major risk factor for the development of insulin resistance,
characterized by impaired stimulation of glucose disposal into muscle. The
mechanisms underlying insulin resistance are unknown. Here we examine the ...
Cited by 50 - Related articles - BL Direct - All 2 versions

Analysis of paradoxical observations on the association between leptin and insulin …

- fasebj.org
RB Ceddia, HA Koistinen, JR Zierath, G … - The FASEB Journal, 2002 - FASEB
Obesity is commonly associated with the development of insulin resistance and
diabetes in humans and rodents. Insulin resistance and diabetes are observed in
lipoatrophic individuals or rodent models of lipoatrophy. Here we focus on ...
Cited by 138 - Related articles - BL Direct - All 4 versions

Differential effects of leptin in regulation of tissue glucose utilization in vivo

- endojournals.org
J Wang, N Chinookoswong, S Scully, M Qi, ZQ … - Endocrinology, 1999 - Endocrine Soc
We have recently shown that leptin enhances systemic insulin sensitivity and
whole body glucose utilization in the rat. This study examines our hypothesis
that leptin has differential effects in regulating glucose utilization ...
Cited by 79 - Related articles - BL Direct - All 4 versions

Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction

- uam.es [PDF] 
S Peralta, JM Carrascosa, N Gallardo, M Ros, … - Biochemical and Biophysical Research …, 2002 - Elsevier
Aged Wistar rats are characterized by leptin and insulin resistance. The
expression of SOCS-3 in hypothalamus increases with ageing. Food restriction
during 3 months decreases obesity Lee index in aged rats with respect to ...
Cited by 34 - Related articles - BL Direct - All 7 versions

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin …

- fasebj.org
AM Hennige, N Stefan, K Kapp, R Lehmann, C … - The FASEB Journal, 2006 - FASEB
Insulin resistance in skeletal muscle is found in obesity and type 2 diabetes. A
mechanism for impaired insulin signaling in peripheral tissues is the inhibition
of insulin action through serine phosphorylation of insulin receptor ...
Cited by 36 - Related articles - BL Direct - All 5 versions

Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of …

- csun.edu [PDF] 
BB Yaspelkis, MK Singh, AD Krisan, DE … - Life Sciences, 2004 - Elsevier
The aim of this investigation was to evaluate if chronic leptin administration
corrects high fat diet-induced skeletal muscle insulin resistance, in part, by
enhancing rates of glucose disposal and if the improvements are accounted ...
Cited by 37 - Related articles - All 4 versions

Vanadate fully stimulates insulin receptor substrate-1 associated phosphatidyl inositol 3- …


JC Molero, C Martı́nez, A Andrés, J … - FEBS letters, 1998 - Elsevier
Vanadate stimulates adipocyte 2-deoxyglucose transport and GLUT-4 translocation
to the membrane through an insulin receptor-independent but
wortmannin-inhibitable pathway. Vanadate stimulates PI 3-kinase in ...
Cited by 24 - Related articles - All 7 versions


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