SE Eckenrode, Q Ruan, P Yang, W Zheng, … - DIABETES-NEW …, 2004 - Am Diabetes Assoc T ype 1 diabetes is a disease manifested when the insulin-producing pancreatic -cells are
de- stroyed by the immune system. Studies using the NOD mouse model, which spontaneously
devel- ops type 1 diabetes, have shown that both B- and T-cells are necessary for the ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org UC Rogner, F Lepault, MC Gagnerault, D Vallois, J … - Diabetes, 2006 - Am Diabetes Assoc The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes
in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H
6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and ... Cited by 10 - Related articles - BL Direct - All 7 versions
PA Lyons - Current opinion in immunology, 2002 - Elsevier The identification of the genetic variants that confer susceptibility to common autoimmune
diseases, such as type 1 diabetes (T1D) and systemic lupus erythematosus (SLE), will provide
significant insight into their pathogenesis as well as identifying potential new targets for ... Cited by 12 - Related articles - All 5 versions
ML Bergman, N Duarte, S Campino, M Lundholm, V … - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and polygenic
disease. The NOD-derived genetic factors that contribute to type 1 diabetes are named Idd
(insulin-dependent diabetes) loci. To date, the biological functions of the majority of the ... Cited by 17 - Related articles - BL Direct - All 4 versions
ML Bergman, C Penha-Goncalves, K Lejon, D … - Diabetologia, 2001 - Springer Non-obese diabetic (NOD) mice spontaneously de- velop autoimmune diabetes, a disease that
closely re- sembles Type I (insulin-dependent) diabetes mellitus in humans [1]. This T-cell-dependent
autoimmune disease is multifactorial and polygenic, with at least 18 separate loci ... Cited by 12 - Related articles - BL Direct - All 3 versions
MG Levisetti, KS Polonsky - Cell Metabolism, 2005 - Elsevier Type 2 diabetes results from an inability of the pancreatic β cell to secrete sufficient insulin to
adequately compensate for the prevailing degree of insulin resistance. Defining the nature of
the β cell defects present in type 2 diabetes has been difficult, in part because human ... Cited by 5 - Related articles - All 8 versions
A Dallas-Pedretti, M McDuffie, K … - Proc Natl Acad Sci USA, 1995 - National Acad Sciences ABSTRACT Identification of diabetes-associated T-cell autoantigens is important for understanding
the immunopa- thology of diabetes and developing improved therapeutic strategies. We have
used a genetic approach to move toward identifying the autoantigen recognized by a ... Cited by 24 - Related articles - BL Direct - All 8 versions
CH Grimm*, UC Rogner, P Avner - Autoimmunity, 2003 - informahealthcare.com Three type 1 diabetes associated regions on distal mouse chromosome 6 have recently been
defined by the construction and analysis of a series of congenic strains, carrying C3H/HeJ genomic
material on a NOD/Lt genetic background. Whilst NOD/Lt alleles at the most distal locus ... Cited by 6 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org N Deruytter, O Boulard, HJ Garchon - Diabetes, 2004 - Am Diabetes Assoc Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition
to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized
as essential, they do not fully explain the MHC-linked genetic component of type 1 ... Cited by 16 - Related articles - BL Direct - All 5 versions
Y Oikawa, E Yamato, F Tashiro, M Yamamoto, N … - FEBS letters, 2005 - Elsevier Cytosolic phospholipase A 2 α (cPLA 2 α) plays an important role in arachidonate pathway. To
investigate the contribution of cPLA 2 α to autoimmune diabetes, we established non-obese
diabetic (NOD) mouse, an excellent model for human type 1 diabetes, deficient in cPLA 2 ... Cited by 10 - Related articles - All 7 versions
