B Nikolic, Y Takeuchi, I Leykin, Y Fudaba, RN Smith, M … - Diabetes, 2004 - Am Diabetes Assoc Bone marrow transplantation from diabetes-resistant strains with complete replacement of the
recipient immune system by the allogeneic donor has led to tolerance to donor islets and cure
of diabetes in a mouse model of type 1 diabetes. However, the ability to tolerize host ... Cited by 56 - Related articles - BL Direct - All 4 versions
GF Beilhack, YC Scheffold, IL Weissman, C Taylor, L … - Diabetes, 2003 - Am Diabetes Assoc Purified hematopoietic stem cells (HSCs) were transplanted into NOD mice to test whether development
of hyperglycemia could be prevented. Engraftment of major histocompatibility complex-mismatched
HSCs was compared with bone marrow (BM) grafts. HSCs differed from BM because ... Cited by 65 - Related articles - BL Direct - All 4 versions
H Li, CL Kaufman, SS Boggs, PC Johnson, … - The Journal of …, 1996 - Am Assoc Immnol Page 1. Mixed Allogeneic Chimerism Induced by a Sublethal Approach Prevents Autoimmune
Diabetes and Reverses lnsulitis in Nonobese Diabetic (NOD) Mice' Hua Li, Christina 1. Kaufman,
Sallie S. Boggs, Peter C. Johnson, Kenneth D. Patrene, and Suzanne T. [Idstad* ... Cited by 103 - Related articles - All 3 versions
- ►hematologylibrary.org - Free from Publisher E Seung, N Iwakoshi, BA Woda, TG Markees, … - …, 2000 - bloodjournal.hematologylibrary.org Recently, it has been hypothesized that procedures that induce tolerance to hematopoietic allografts
may be able to obviate any requirement for lethal myeloablative preparation and to prevent
GVHD. 1 One class of promising tolerance induction protocols is based on blockade of ... Cited by 126 - Related articles - BL Direct - All 6 versions
- ►hematologylibrary.org ST Ildstad, PM Chilton, H Xu, MA Domenick, … - Blood, 2005 - bloodjournal.hematologylibrary.org Bone marrow transplantation blocks diabetes pathogenesis and reverses autoimmunity in nonobese
diabetic (NOD) mice. However, there is a greater barrier to engraftment in the context of
autoimmunity. In the present study, we characterized which recipient cells influence ... Cited by 10 - Related articles - All 5 versions
- ►jimmunol.org DV Serreze, MA Osborne, YG Chen, HD … - The Journal of …, 2006 - Am Assoc Immnol In both humans and NOD mice, particular combinations of MHC genes provide the primary risk
factor for development of the autoreactive T cell responses causing type 1 diabetes (T1D).
Conversely, other MHC variants can confer dominant T1D resistance, and previous ... Cited by 5 - Related articles - BL Direct - All 7 versions
- ►hematologylibrary.org Y Liang, T Huang, C Zhang, I Todorov, M … - …, 2005 - bloodjournal.hematologylibrary.org Prevention of autoimmune diabetes and induction of islet transplantation tolerance in nonobese
diabetic (NOD) mice can be reached by induction of mixed chimerism via bone marrow transplantation
(BMT), but this procedure requires total body irradiation (TBI) conditioning of the ... Cited by 34 - Related articles - All 6 versions
CL Kaufman, H Li, ST Ildstad - The Journal of Immunology, 1997 - Am Assoc Immnol Complete replacement of the immune system via allogeneic bone marrow transplantation ...
T ype 1 diabetes is a systemic autoimmune disease of mul- tifactorial pathogenesis in which
destruction of the insu- lin-producing p cells of the pancreatic islet leads to ex- ogenous ... Cited by 23 - Related articles - BL Direct - All 4 versions
GF Beilhack, RR Landa, MA Masek, JA Shizuru - Diabetes, 2005 - Am Diabetes Assoc Progression to hyperglycemia in young nonobese diabetic (NOD) mice is blocked by the transplantation
of hematopoietic cells mismatched at the major histocompatibility complex (MHC). Because the
NOD MHC class II allele, IA g7 , is the primary disease susceptibility gene, it is logical to ... Cited by 12 - Related articles - All 5 versions
- ►nih.gov E Seung, JP Mordes, AA Rossini, DL … - Journal of Clinical …, 2003 - Am Soc Clin Investig Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic
potential. Realization of that potential has been impeded by the need for myeloablative conditioning
of the host and development of graft-versus-host disease (GVHD). To surmount these ... Cited by 61 - Related articles - BL Direct - All 9 versions
