P Achenbach, K Warncke, J Reiter, HE Naserke … - Diabetes, 2004 - Am Diabetes Assoc Family history of type 1 diabetes and autoantibodies to the islet antigens
insulin (IAA), glutamate decarboxylase (GADA), and the protein tyrosine
phosphatase-like protein IA-2 (IA-2A) are strong predictors of type 1 ... Cited by 91 - Related articles - BL Direct - All 6 versions
- ►annals.org [PDF] M Hummel, E Bonifacio, S Schmid, M Walter, A … - Annals of internal medicine, 2004 - Am Coll Physicians Brief Communication: Early Appearance of Islet Autoantibodies ... Predicts
Childhood Type 1 Diabetes in Offspring of Diabetic Parents ... Michael Hummel,
MD; Ezio Bonifacio, PhD; Sandra Schmid, PhD; Markus Walter, MD; Annette ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JP Krischer, DD Cuthbertson, L Yu, T Orban, … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc There were 1010 (5.9%) relatives with a single autoantibody on initial screening
and 394 (2.3%) with two or more autoantibodies. GAA was more sensitive than ICA
[GAA, 91% (357 of 394); ICA, 82% (324 of 394)] in the detection of multiple ... Cited by 69 - Related articles - BL Direct - All 4 versions
JM LaGasse, MS Brantley, NJ Leech, RE … - Diabetes Care, 2002 - Am Diabetes Assoc RESULTS—Six subjects developed diabetes (median interval 2.8 years), all from
among the 12 individuals with multiple d-aab, representing 50% positive
predictive value (95% CI 25–75%) and 100% sensitivity (58–100%). Among ... Cited by 76 - Related articles - BL Direct - All 5 versions
K Decochez, I De Leeuw, B Keymeulen, C … - Diabetologia, 2002 - Springer Aims/hypothesis. Multiple islet autoantibody positivity is currently believed to
best predict progression to Type I (insulin-dependent) diabetes mellitus. We
com- pared its predictive value with that of positivity for a particular ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►nih.gov P Achenbach, K Koczwara, A Knopff, H Naserke … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Children at risk for type 1 diabetes can develop early insulin autoantibodies
(IAAs). Many, but not all, of these children subsequently develop multiple islet
autoantibodies and diabetes. To determine whether disease progression is ... Cited by 66 - Related articles - BL Direct - All 10 versions
- ►endojournals.org JM Barker, KJ Barriga, L Yu, D Miao, HA … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Diabetes Autoimmunity Study in the Young (DAISY) has followed 1972 children for
islet autoimmunity and diabetes: 837 first-degree relatives of persons with type
1 diabetes and 1135 general population newborns identified through human ... Cited by 102 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] E Bonifacio, V Lampasona, L Bernasconi, AG … - Diabetes, 2000 - Am Diabetes Assoc GAD is a major target of autoimmunity in preclinical type 1 diabetes. Here we
examine the maturation of the humoral response to GAD epitopes sequentially from
birth to diabetes onset or current follow-up in 29 GAD antibody (GADA)+ o ... Cited by 61 - Related articles - BL Direct - All 4 versions
S Hoppu, MS Ronkainen, P Kulmala, HK … - Clinical and experimental immunology, 2004 - pubmedcentral.nih.gov We observed 42 initially non-diabetic siblings of affected children to
characterize the humoral immune response to the 65 kDa isoform of glutamic acid
decarboxylase (GAD65) in preclinical type I diabetes. During the ... Cited by 15 - Related articles - BL Direct - All 7 versions
- ►jimmunol.org E Bonifacio, M Scirpoli, K Kredel, M … - The Journal of Immunology, 1999 - Am Assoc Immnol The islet autoimmunity of preclinical type 1 diabetes remains poorly
characterized in humans. In this paper, the IgG subclass response to the islet
autoantigens insulin, glutamic acid decarboxylase, and IA-2 was studied ... Cited by 79 - Related articles - BL Direct - All 3 versions
