Y Liang, MC Osborne, BP Monia, S Bhanot, … - Diabetes, 2004 - Am Diabetes Assoc Excess glucagon levels contribute to the hyperglycemia associated with type 2
diabetes. Reducing glucagon receptor expression may thus ameliorate the
consequences of hyperglucagonemia and improve blood glucose control in ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang, DM … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to
hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated
in the etiology of this condition; however, effective therapies to block ... Cited by 46 - Related articles - BL Direct - All 6 versions
JC Parker, KM Andrews, MR Allen, JL Stock, … - Biochemical and Biophysical Research …, 2002 - Elsevier The action of glucagon in the liver is mediated by G-coupled receptors. To
examine the role of glucagon in glucose homeostasis, we have generated mice in
which the glucagon receptor was inactivated (GR −/− mice). Blood ... Cited by 44 - Related articles - BL Direct - All 6 versions
KF Petersen, JT Sullivan - Diabetologia, 2001 - Springer Fasting hyperglycaemia in patients with poorly con- trolled Type II
(non-insulin-dependent) diabetes mellitus is closely associated with increased
rates of glucose production which in turn can be ascribed to increased ... Cited by 62 - Related articles - BL Direct - All 3 versions
RW Gelling, XQ Du, DS Dichmann, J Rømer, H … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic
α cells in response to low blood glucose. To examine the role of glucagon in
glucose homeostasis, mice were generated with a null mutation of the ... Cited by 80 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org SA Qureshi, R Candelore… - Diabetes, 2004 - Am Diabetes Assoc Glucagon maintains glucose homeostasis during the fasting state by promoting
hepatic gluconeogenesis and glycogenolysis. Hyperglucagonemia and/or an elevated
glucagon-to-insulin ratio have been reported in diabetic patients and ... Cited by 18 - Related articles - BL Direct - All 5 versions
CL Brand, B Rolin, PN Jørgensen, I Svendsen, … - Diabetologia, 1994 - Springer Summary The role of glucagon in diabetic hyper- glycaemia has been a matter of
controversy because of difficulties in the production of selective glucagon
deficiency. We developed a high-capacity (40 nmol/ ml), high-affinity (0.6 ... Cited by 47 - Related articles - BL Direct - All 4 versions
DG Johnson, CU Goebel, VJ Hruby, MD … - Science, 1982 - sciencemag.org The glucagon analog [lN alpha-trinitrophenylhistidine, 12-homoarginine]-glucagon
(THG) was examined for its ability to lower blood glucose concentrations in rats
made diabetic with streptozotocin. In vitro, THG is a potent antagonist of ... Cited by 44 - Related articles - All 3 versions
GC Webb, MS Akbar, C Zhao, HH Swift, DF … - Diabetes, 2002 - Am Diabetes Assoc Prohormone convertase 2 (PC2) plays an essential role in the processing of
proglucagon to mature active glucagon in pancreatic α-cells (J Biol Chem
276:27197–27202, 2001). Mice lacking PC2 demonstrate multiple defects, ... Cited by 33 - Related articles - BL Direct - All 5 versions
CL Brand, PN Jørgensen, I Svendsen, JJ … - Diabetes, 1996 - Am Diabetes Assoc Effects of glucagon immunoneutralization on plasma glucose, insulin, and
glucagon were studied 2-4 h after intravenous injection of a high-affinity,
monoclonal glucagon antibody into normal as well as moderately and severely ... Cited by 41 - Related articles - BL Direct - All 4 versions
