C Steele, WA Hagopian, S Gitelman, U … - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes, a chronic autoimmune disease, causes destruction of
insulin-producing β-cells over a period of years. Although many markers of the
autoimmune process have been described, none can convincingly predict the ... Cited by 54 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org NA Sherry, EB Tsai, KC Herold - Diabetes, 2005 - Am Diabetes Assoc Despite extensive and ongoing investigations of the immune mechanisms of
autoimmune diabetes in humans and animal models, there is much less information
about the natural history of insulin secretion before and after the ... Cited by 37 - Related articles - BL Direct - All 6 versions
O Snorgaard, LH Lassen, C Binder - Diabetes Care, 1992 - Am Diabetes Assoc OBJECTIVE--To study the natural history of beta-cell function from onset of IDDM
to expected deterioration of insulin (C-peptide) secretion and to identify
different patterns of decline, if any. RESEARCH DESIGN AND METHODS--A ... Cited by 19 - Related articles - All 6 versions
- ►diabetesjournals.org MW Steffes, S Sibley, M Jackson, W Thomas - Diabetes Care, 2003 - Am Diabetes Assoc In patients with type 1 diabetes, measurement of connecting peptide (C-peptide),
cosecreted with insulin from the islets of Langerhans, permits estimation of
remaining β-cell secretion of insulin. In this retrospective analysis to ... Cited by 112 - Related articles - BL Direct - All 5 versions
J Daaboul, D Schatz - Reviews in Endocrine & Metabolic Disorders, 2003 - Springer Type 1 diabetes mellitus (T1DM) is an immune medi- ated disease, which results
from chronic and selective de- struction of pancreatic islet beta cells.
Resultant loss of insulin producing cells leads to hyperglycemia, polyuria, ... Cited by 16 - Related articles - BL Direct - All 3 versions
EB Tsai, NA Sherry, JP Palmer, KC Herold - Diabetologia, 2006 - Springer Abstract An understanding of the natural history of beta cell responses is an
essential prerequisite for interventional studies designed to prevent or treat
type 1 diabetes. Here we review published data on changes in insulin ... Cited by 33 - Related articles - BL Direct - All 3 versions
JP Palmer, GA Fleming, CJ Greenbaum, KC … - Diabetes, 2004 - ncbi.nlm.nih.gov The underlying cause of type 1 diabetes, loss of beta-cell function, has become
the therapeutic target for a number of interventions in patients with type 1
diabetes. Even though insulin therapies continue to improve, it remains ... Cited by 88 - Related articles - BL Direct
DV Serreze, PA Silveira - B cell biology in autoimmunity, 2002 - books.google.com Nemazee D (ed): B Cell Biology in Autoimmunity. Curr Dir Autoimmun. Basel,
Karger, 2003, vol 6, pp 212-227 The Role of B Lymphocytes as Key
Antigen-Presenting Cells in the Development of T Cell-Mediated Autoimmune ... Cited by 28 - Related articles - BL Direct - All 5 versions
L Lazar, R Ofan, N Weintrob, A Avron, M Tamir, … - Diabetes/Metabolism Reviews - interscience.wiley.com Type 1 diabetes mellitus (T1DM) is a T-cell-mediated autoimmune disease that
leads to the destruction of insulin-producing beta cells. Treatment with
DiaPep277, a peptide derived from heat-shock protein 60 (hsp60), has been ... Cited by 22 - Related articles - BL Direct - All 3 versions
