- ►pubget.com [PDF] F Payne, DJ Smyth, R Pask, BJ Barratt, JD … - Diabetes, 2004 - Am Diabetes Assoc The diabetes-prone BioBreeding (BB) and Komeda diabetes-prone (KDP) rats are
both spontaneous animal models of human autoimmune, T-cell-associated type 1
diabetes. Both resemble the human disease, and consequently, susceptibility ... Cited by 25 - Related articles - BL Direct - All 5 versions
R Kosoy, N Yokoi, S Seino, P Concannon - Genes and Immunity, 2004 - nature.com CBLB was evaluated as a candidate gene for type 1 diabetes (T1D) susceptibility
based on its association with autoimmunity in animal models and its role in
T-cell costimulatory signaling. Cblb is one of the two major diabetes ... Cited by 12 - Related articles - BL Direct - All 2 versions
DH Moralejo, HA Park, SJ Speros, AJ … - Journal of autoimmunity, 2003 - Elsevier Peripheral T cell lymphopenia (lyp) in the BioBreeding (BB) rat is linked to a
frameshift mutation in Ian5, a member of the Immune Associated Nucleotide (Ian)
gene family on rat chromosome 4. This lymphopenia leads to type 1 (insulin- ... Cited by 20 - Related articles - All 5 versions
K Komeda, M Noda, K Terao, N Kuzuya, M … - ENDOCRINE JOURNAL-TOKYO-, 1998 - sciencelinks.jp Abstract;Diabetes mellitus in Long-Evans Tokushima Lean(LETL) rats closely
resembles type 1 diabetes in human beings, eg, no gender differences in the
incidence of diabetes and no T lymphopenia. Although the LETL rats have ... Cited by 19 - Related articles - Cached - BL Direct - All 3 versions
- ►physiology.org … , T Michalkiewicz, RA Ettinger, EA Rutledge, … - Physiological Genomics, 2004 - Am Physiological Soc A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5)
coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue
approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine ... Cited by 28 - Related articles - All 4 versions
N Yokoi - Exp Anim, 2005 - 万方数据资源系统 Type 1 diabetes mellitus is an autoimmune disease involving both environmental
and genetic factors. Genetic analyses in humans and rodents have shown that the
major histocompatibility complex (MHC) is a major genetic factor and that ... Cited by 7 - Related articles - All 4 versions
- ►highwire.org R Bergholdt, C Taxvig, S Eising, J Nerup, F … - Journal of leukocyte biology, 2005 - jleuk.highwire.org Type 1 diabetes (T1D) is a multifactorial disease with genetic and environmental
components involved. Recent studies of an animal model of T1D, the Komeda
diabetes-prone rat, have demonstrated that the Casitas-B-lineage lymphoma b ... Cited by 20 - Related articles - All 6 versions
- ►molbiolcell.org T Sandal, L Aumo, L Hedin, BT Gjertsen, SO … - Molecular biology of the cell, 2003 - Am Soc Cell Biol Protein phosphatase-directed toxins such as okadaic acid (OA) are general
apoptosis inducers. We show that a protein (inhibitor of radiation- and
OA-induced apoptosis, Irod/Ian5), belonging to the family of ... Cited by 38 - Related articles - BL Direct - All 4 versions
N Yokoi, M Namae, M Fuse, HY Wang, T Hirata … - Experimental animals, 2003 - sciencelinks.jp Abstract;The Komeda diabetes-prone(KDP) rat is a spontaneous animal model of
human autoimmune type 1 diabetes. By positional cloning of the non-MHC major
susceptibility locus Iddm/kdp1, we recently identified a nonsense mutation ... Cited by 9 - Related articles - Cached - BL Direct - All 3 versions
