- ►diabetesjournals.org AD Mooradian, MJ Haas, NCW Wong - Diabetes, 2004 - Am Diabetes Assoc Cardiovascular disease continues to be the leading cause of mortality in diabetes. One of the
factors contributing to the increased risk is the high prevalence rate of low plasma concentrations
of HDL cholesterol. Multiple potential mechanisms account for the cardioprotective effects ... Cited by 41 - Related articles - BL Direct - All 5 versions
AD Mooradian, MJ Haas, NCW Wong - Diabetes, 2004 - Am Diabetes Assoc Cardiovascular disease continues to be the leading cause of mortality in diabetes. One of the
factors contributing to the increased risk is the high preva- lence rate of low plasma concentrations
of HDL choles- terol. Multiple potential mechanisms account for the cardioprotective ... Related articles - All 2 versions
MJ Haas, M Horani, A Mreyoud, B Plummer, NCW … - BBA-General Subjects, 2003 - Elsevier Plasma inflammatory cytokines are elevated in obese subjects as well as in those with type 2
diabetes. This presumably results in systemic insulin resistance, characterized by a pro-atherogenic
plasma lipid profile and reduced apolipoprotein AI (apoAI) protein levels. To determine ... Cited by 24 - Related articles - All 5 versions
Z Vajo, JG Terry, EA Brinton - Atherosclerosis, 2002 - Elsevier High-density lipoprotein (HDL) particles without apolipoprotein A-II (Lp AI) may be more
anti-atherogenic than HDL with apo A-II (Lp AI/AII) and Lp AI is reported selectively to be reduced
in cases of intra-abdominal obesity. We explored the mechanisms of this reduction by ... Cited by 26 - Related articles - All 8 versions
AD Mooradian - Growth Hormone & IGF Research, 2001 - Elsevier Obesity is a growing public health problem worldwide. It is a particularly common problem amongindividuals
with type 2 diabetes mellitus. The magnitude of obesity, the central location of fat, and a history
of weight gain are independent risks for developing diabetes mellitus. Potential factors ... Cited by 25 - Related articles - BL Direct - All 2 versions
- ►jbc.org K Murao, Y Wada, T Nakamura, AH Taylor, AD … - Journal of Biological …, 1998 - ASBMB We have examined the regulation of apolipoprotein AI (apoA-I) gene expression in response
to glucose and insulin. In Hep G2 cells, endogenous apoA-I mRNA was suppressed by one-half
or induced 2-fold following 48 h of exposure to high concentrations of glucose (22.4 mM) ... Cited by 74 - Related articles - BL Direct - All 5 versions
- ►daegu.ac.kr [PDF] A Beers, MJ Haas, NCW Wong, AD Mooradian - Biochemistry, 2006 - pubs.acs.org Plasma high-density lipoprotein and apolipoprotein AI (apoAI) levels are suppressed by tumor
necrosis factor α. To determine the molecular mechanisms responsible for the effect of TNF α
on the apoAI promoter activity, HepG2 cells were exposed to both genetic and ... Cited by 7 - Related articles - All 4 versions
MJ Haas, MH Horani, NCW Wong, AD Mooradian - Metabolism, 2004 - Elsevier Insulin induces transcription of the hepatic apolipoprotein AI (apo AI) gene by increasing Sp1
binding to the promoter. To determine the effect of fatty acids on this process, HepG2 cells cotransfected
with the plasmid pAI.474.CAT containing the full-length apo AI promoter and the Sp1- ... Cited by 8 - Related articles - All 9 versions
- ►endojournals.org AD Mooradian, MJ Haas, NCW Wong - Endocrine reviews, 2006 - Endocrine Soc One of the factors contributing to the increased risk of developing premature atherosclerosis
is low plasma concentrations of high-density lipoprotein (HDL) cholesterol (HDLc). Multiple potential
mechanisms account for the cardioprotective effects of HDL and its main protein ... Cited by 25 - Related articles - BL Direct - All 5 versions
JK Lam, S Matsubara, K Mihara, X Zheng, AD … - Biochemistry, 2003 - pubs.acs.org Grant support for this project came from the Canadian Institute for Health Research (CIHR) and
the Heart and Stroke Foundation of Canada (HSF). X-LZ is the recipient of a scholarship award
from CIHR/HSF partnership. NCWW is the recipient of a scientist award from the Alberta ... Cited by 27 - Related articles - BL Direct - All 3 versions
