- ►diabetesjournals.org T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, … - Diabetes, 2004 - Am Diabetes Assoc Insulin and glucose together have been previously shown to regulate hepatic sterol regulatory
element-binding protein (SREBP)-1c expression. We sought to explore the nutritional regulation
of lipogenesis through SREBP-1c induction in a setting where effects of sugars versus ... Cited by 50 - Related articles - BL Direct - All 6 versions
T Ide, H Shimano, N Yahagi, T Matsuzaka, M … - Nature cell …, 2004 - lipid.umin.ne.jp Insulin receptor substrate 2 (IRS-2) is the main mediator of insulin signalling in the liver, controlling
insulin sensitivity. Sterol regulatory element binding proteins (SREBPs) have been established
as transcriptional regulators of lipid synthesis. Here, we show that SREBPs directly ... Cited by 125 - Related articles - BL Direct - All 5 versions
AH Hasty, H Shimano, N Yahagi, M Amemiya-Kudo … - Journal of Biological …, 2000 - ASBMB In vivo studies suggest that sterol regulatory element-binding protein (SREBP)-1 plays a key
role in the up-regulation of lipogenic genes in the livers of animals that have consumed excess
amounts of carbohydrates. In light of this, we sought to use an established mouse ... Cited by 89 - Related articles - BL Direct - All 7 versions
A Takahashi, K Motomura, T Kato, T Yoshikawa, Y … - Diabetes, 2005 - Am Diabetes Assoc Influx of excess fatty acids and the resultant accumulation of intracellular triglycerides are linked
to impaired insulin secretion and action in the pathogenesis of type 2 diabetes. Sterol regulatory
element-binding protein (SREBP)-1c is a transcription factor that controls cellular ... Cited by 43 - Related articles - All 5 versions
Y Nakagawa, H Shimano, T Yoshikawa, T Ide, M … - Nature medicine, 2006 - plaza.umin.ac.jp Using an expression cloning strategy, we have identified TFE3, a basic helix-loop-helix
protein, as a transactivator of metabolic genes that are regulated through an E-box in their
promoters. Adenovirus-mediated expression of TFE3 in hepatocytes in culture and in vivo ... Cited by 29 - Related articles - BL Direct - All 9 versions
- ►tsukuba.ac.jp [PDF] Y Takeuchi, N Yahagi, Y Nakagawa, T Matsuzaka, … - … and Biophysical Research …, 2007 - Elsevier Sterol regulatory element-binding protein (SREBP)-1c is the master regulator of lipogenic gene
expression in liver. The mRNA abundance of SREBP-1c is markedly induced when animals
are refed after starvation, although the regulatory mechanism is so far unknown. To ... Cited by 4 - Related articles - All 13 versions
- ►cnfindpark.cn KL Stanhope, SC Griffen, BR Bair, MM … - American Journal of …, 2008 - ajcn.cnfindpark.cn 2 Supported in part with funding from Pepsico, Inc. The project also received support from the
UC Davis Clinical and Translational Science Center (grant UL1 RR024146) and the US Department
of Agriculture. PJH's laboratory also receives support from NIH grants R01 HL075675, ... Cited by 25 - Related articles - BL Direct - All 14 versions
H Ono, H Shimano, H Katagiri, N Yahagi, H Sakoda, Y … - Diabetes, 2003 - Am Diabetes Assoc Akt is critical in insulin-induced metabolism of glucose and lipids. To investigate functions induced
by hepatic Akt activation, a constitutively active Akt, NH 2 -terminally myristoylation signal-attached
Akt (myr-Akt), was overexpressed in the liver by injecting its adenovirus into mice. Hepatic ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►umin.ac.jp [PDF] T Kato, H Shimano, T Yamamoto, T Yokoo, Y Endo, M … - Cell Metabolism, 2006 - Elsevier Granuphilin is a crucial component of the docking machinery of insulin-containing vesicles to
the plasma membrane. Here, we show that the granuphilin promoter is a target of
SREBP-1c, a transcription factor that controls fatty acid synthesis, and MafA, a β cell ... Cited by 25 - Related articles - All 8 versions
P Ferré, M Foretz, D Azzout-Marniche, D … - Biochemical Society …, 2001 - bst.portlandpress.com Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms
aimed at maintaining energy homeostasis in mammals. When the diet is rich in
carbohydrates, secreted insulin stimulates the expression of genes for enzymes involved ... Cited by 13 - Related articles - Cached - BL Direct - All 10 versions
