- ►diabetesjournals.org MA Christoffolete, CCG Linardi, L de Jesus, KN Ebina, … - Diabetes, 2004 - Am Diabetes Assoc The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3′,5-triiodothyronine
(T3), the disruption of which (Dio2 −/− ) results in brown adipose tissue (BAT)-specific hypothyroidism
in an otherwise euthyroid animal. In the present studies, cold exposure increased Dio2 ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►nih.gov LA de Jesus, SD Carvalho, MO Ribeiro, M … - Journal of Clinical …, 2001 - Am Soc Clin Investig Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned
cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown
adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′- ... Cited by 112 - Related articles - BL Direct - All 8 versions
L Ng, RJ Goodyear, CA Woods, MJ … - Proceedings of the …, 2004 - National Acad Sciences The later stages of cochlear differentiation and the developmental onset of hearing require thyroid
hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely
that other factors modify TR activity during cochlear development. The mouse cochlea ... Cited by 53 - Related articles - BL Direct - All 9 versions
DLS Germain, A Hernandez, MJ Schneider, VA Galton - Thyroid, 2005 - liebertonline.com The deiodinases function at a prereceptor level in tissues to modulate the concentrations, and
thus the actions, of thyroid hormones. Although much has been learned in the last two decades
about the biochemical proper- ties and expression patterns of these enzymes, a complete ... Cited by 32 - Related articles - BL Direct - All 4 versions
AC Bianco, JE Silva - American Journal of Physiology- …, 1988 - Am Physiological Soc Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao
Paulo, ... 05508 Sao Paulo, Brazil; and Howard Hughes Medical Institute Laboratory, Brigham
and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 Cited by 46 - Related articles - All 3 versions
M Reis, M Farage, L Meis - Molecular membrane biology, 2002 - informahealthcare.com Summary This report measured the amount of heat released during Ca2+ transport and ATP
hydrolysis by vesicles derived from the sarcoplasmic reticulum of rabbit slow (SM) and fast
(FM) muscle. During ATP hydrolysis, part of the chemical energy released is used to ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►endojournals.org MA Christoffolete, R Ribeiro, P Singru, C Fekete, WS … - Endocrinology, 2006 - Endocrine Soc T 4 , the main product of thyroid secretion, is a critical signal in plasma that mediates the
TSH-negative feedback mechanism. As a prohormone, T 4 must be converted to T 3 to acquire
biological activity; thus, type 2 iodothyronine deiodinase (D2) is expected to play a critical ... Cited by 22 - Related articles - BL Direct - All 7 versions
DD Brown - Thyroid, 2005 - liebertonline.com Valerie Galton's prediction over 40 years ago that deiodinases would be important in amphibian
metamor- phosis has been confirmed. Expression of iodothyronine deiodinase type 2 (D2) and
type 3 (D3) occurs in em- bryogenesis at relevant locations long before the thyroid gland ... Cited by 25 - Related articles - BL Direct - All 6 versions
W Croteau, JE Bodwell, JM Richardson, DLS … - Journal of Biological …, 1998 - ASBMB The iodothyronine deiodinases are a family of oxidoreductases that catalyze the removal of iodide
from thyroid hormones. Each of the three isoforms contain selenocysteine at its active site and
several cysteine residues that may be important for catalytic activity. Of particular interest ... Cited by 17 - Related articles - BL Direct - All 4 versions
D Mentuccia, L Proietti-Pannunzi, K Tanner, V Bacci, TI … - Diabetes, 2002 - ncbi.nlm.nih.gov Thyroid hormone action is an important determinant of energy and glucose metabolism. T4 metabolism
is regulated by the deiodinases of which type 2 is expressed in humans in skeletal muscle and
brown adipose tissue, where its transcription is stimulated by the beta-3 adrenergic ... Cited by 57 - Related articles - BL Direct - All 2 versions
