IG Obrosova, F Li, OI Abatan, MA Forsell, K Komjáti, P … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but
the mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase
(PARP) activation, a downstream effector of oxidant-induced DNA damage, is an ... Cited by 88 - Related articles - BL Direct - All 10 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI Abatan, T … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and high-energy
phosphates, activates protein kinase C, and affects gene expression in various tissues. This
study was designed to charac- terise the effects of the potent, orally active ... Cited by 38 - Related articles - BL Direct - All 11 versions
O Ilnytska, VV Lyzogubov, MJ Stevens, VR Drel, N … - Diabetes, 2006 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental mechanism in
the pathogenesis of diabetes complications including diabetic neuropathy. This study evaluated
the role of PARP in diabetic sensory neuropathy. The experiments were performed in ... Cited by 28 - Related articles - BL Direct - All 10 versions
IG Obrosova, P Pacher, C Szabó, Z Zsengeller, H … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on diabetes-induced
oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation. In animal
experiments, control and streptozotocin-induced diabetic rats were treated with or without ... Cited by 73 - Related articles - All 8 versions
- ►fasebj.org [PDF] AG Minchenko, MJ Stevens, L White, OI Abatan, K … - The FASEB Journal, 2003 - FASEB The FASEB Journal express article 10.1096/fj.03-0013fje. Published online June 3, 2003. ...
Katalin Komjáti, fl,§ Pal Pacher, fl Csaba Szabó, fl and Irina G. Obrosova † ... *Department of
Anesthesiology Thomas Jefferson University, Philadelphia, Pennsylvania; † Department ... Cited by 68 - Related articles - BL Direct - All 7 versions
L Zheng, C Szabó, TS Kern - Diabetes, 2004 - Am Diabetes Assoc The current study investigated the role of poly(ADP-ribose) polymerase (PARP) in the development
of diabetic retinopathy. Activity of PARP was increased in whole retina and in endothelial cells
and pericytes of diabetic rats. Administration of PJ-34 (a potent PARP inhibitor) for 9 ... Cited by 98 - Related articles - BL Direct - All 5 versions
IG Obrosova, VR Drel, P Pacher, O Ilnytska, ZQ Wang, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of diabetes
complications, is considered a downstream effector of oxidative-nitrosative stress. However,
some recent findings suggest that it is not necessarily the case and that PARP activation ... Cited by 38 - Related articles - BL Direct - All 11 versions
IG Obrosova, AG Minchenko, RN Frank, GM … - International journal of …, 2004 - inotekcorp.com INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 14: 55-64, 2004
Poly(ADP-ribose) polymerase inhibitors counteract diabetes» and hypoxia-induced retinal vascular
endothelial growth factor overexpression IRINA G. OBROSOVA1, ALEXANDER G. ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org F Li, VR Drel, C Szabó, MJ Stevens, IG Obrosova - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a novel approach
to treatment of experimental peripheral diabetic neuropathy (PDN). However, long-term inhibition
of PARP, an enzyme involved in DNA repair, can potentially result in premature aging, ... Cited by 25 - Related articles - All 5 versions
