- ►diabetesjournals.org FR DeRubertis, PA Craven, MF Melhem, EM Salah - Diabetes, 2004 - Am Diabetes Assoc The effects of overexpression of Cu 2+ /Zn 2+ superoxide dismutase-1 (SOD-1) on indexes of
renal injury were compared in 5-month-old nontransgenic (NTg) db/db mice and db/db mice
hemizygous for the human SOD-1 transgene (SOD-Tg). Both diabetic groups exhibited ... Cited by 59 - Related articles - BL Direct - All 4 versions
PA Craven, MF Melhem, SL Phillips, FR DeRubertis - Diabetes, 2001 - Am Diabetes Assoc Ex vivo and in vitro observations implicate superoxide as a mediator of cell injury in
diabetes, but in vivo evidence is lacking. In the current studies, parameters of glomerular injury
were examined in hemizygous nondiabetic transgenic mice (SOD) and streptozotocin- ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org MF Melhem, PA Craven, J Liachenko, FR … - Journal of the American …, 2002 - Am Soc Nephrol ABSTRACT. Previous studies demonstrated that 2 mo of dietary supplementation with -lipoic
acid (LA) prevented early glomerular injury in non-insulin-treated streptozotocin diabetic rats
(D). The present study examined the effects of chronic LA supplementation (30 mg/kg ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org D Koya, K Hayashi, M Kitada, A Kashiwagi, R … - Journal of the American …, 2003 - Am Soc Nephrol Diabetic nephropathy is a leading cause of end-stage renal failure, accounting for 35 to 40%
of all new cases that require dialysis therapy worldwide. Recent clinical studies clearly demonstrated
that hyperglycemia is an important causal factor in mediating the development and ... Cited by 81 - Related articles - BL Direct - All 6 versions
NB Bishara, ME Dunlop, TV Murphy, IA Darby, … - Journal of cellular … - interscience.wiley.com Studies have shown diabetes to be associated with alterations in composition of extracellular
matrix and that such proteins modulate signal transduction. The present studies examined if
non-enzymatic glycation of fibronectin or a mixed matrix preparation (EHS) alters ... Cited by 20 - Related articles - BL Direct - All 4 versions
FR DeRubertis, PA Craven, MF Melhem - Metabolism, 2007 - Elsevier Indices of renal injury and oxidative stress were examined in mice with deficiency of cytosolic
Cu 2+ /Zn 2+ superoxide dismutase (SOD1−/−, KO) and their wild-type (WT) littermates with
streptozotocin-induced diabetes. After 5 weeks of diabetes, KO diabetic (D) but not WT-D ... Cited by 12 - Related articles - All 10 versions
- ►asnjournals.org JM Li, AM Shah - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol The NADPH oxidase was originally discovered in neutrophils, where it is a potent source of millimolar
quantities of superoxide (O 2 - ) during phagocytosis and plays a vital role in nonspecific host
defense (1). It comprises a membrane-associated cytochrome b 558 , composed of one ... Cited by 104 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Kiritoshi, T Nishikawa, K Sonoda, D Kukidome, T … - Diabetes, 2003 - Am Diabetes Assoc Hyperglycemia increases the production of reactive oxygen species (ROS) from the mitochondrial
electron transport chain in bovine endothelial cells. Because several studies have postulated
a role for prostaglandins (PGs) in the glomerular hyperfiltration seen in early diabetes, we ... Cited by 126 - Related articles - BL Direct - All 4 versions
EP Feener, P Xia, T Inoguchi, T Shiba, M … - Contributions to …, 1996 - ncbi.nlm.nih.gov 1: Contrib Nephrol. 1996;118:180-7. Role of protein kinase C in glucose- and angiotensin
II-induced plasminogen activator inhibitor expression. Feener EP, Xia P, Inoguchi T, Shiba T,
Kunisaki M, King GL. Research Division, Joslin Diabetes Center, Boston, Mass., USA. ... Cited by 19 - Related articles - BL Direct - All 2 versions
- ►asnjournals.org MF MELHEM, PA CRAVEN, FR … - Journal of the American …, 2001 - Am Soc Nephrol Abstract. Antioxidants, in particular vitamin E (VE), have been reported to protect against diabetic
renal injury. -Lipoic acid (LA) has been found to attenuate diabetic peripheral neuropathy, but
its effects on nephropathy have not been examined. In the present study, parameters of ... Cited by 73 - Related articles - BL Direct - All 6 versions
