- ►diabetesjournals.org N Shanmugam, G Gonzalo, T Irene, R Natarajan - Diabetes, 2004 - Am Diabetes Assoc The cyclooxygenase (COX)-2 enzyme has been implicated in the pathogenesis of several inflammatory
diseases. However, its role in diabetic vascular disease is unclear. In this study, we evaluated the
hypothesis that diabetic conditions ... Cited by 35 - Related articles - BL Direct - All 4 versions
N Shanmugam, YS Kim, L Lanting, R Natarajan - Journal of Biological …, 2003 - ASBMB Cyclooxygenase-2 (COX-2) enzyme and its inflammatory products such as prostaglandin E 2 (PGE 2 )
have been implicated in the pathogenesis of several inflammatory diseases. However their role in
diabetic vascular disease is ... Cited by 83 - Related articles - BL Direct - All 4 versions
SJ Persaud, CJ Burns, VD Belin, PM Jones - Diabetes, 2004 - Am Diabetes Assoc Cyclo-oxygenase (COX), the enzyme responsible for conversion of arachidonic acid to prostanoids,
exists as two isoforms. In most tissues, COX-1 is a constitutive enzyme involved in
prostaglandin-mediated ... Cited by 11 - Related articles - BL Direct - All 5 versions
SH Lee, HG Woo, EJ Baik, CH Moon - Life sciences, 2000 - Elsevier The changes in vascular prostaglandin production are implicated in the derangement of vascular
reactivity in diabetes. However, the mechanism of altered prostaglandin (PG) production in diabetes
is largely unknown. In this study, ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►jbc.org MR Heitmeier, CB Kelly, NJ Ensor, KA Gibson, KG … - Journal of Biological …, 2004 - ASBMB Type I diabetes mellitus is an autoimmune disease characterized by the selective destruction of the
insulin-secreting -cell found in pancreatic islets of Langerhans. Cytokines such as interleukin-1
(IL-1), interferon- (IFN- ), and ... Cited by 17 - Related articles - All 4 versions
N Shanmugam, MA Reddy, R Natarajan - Journal of Biological Chemistry, 2008 - ASBMB Advanced glycation end products play major roles in diabetic complications. They act via their
receptor RAGE to induce inflammatory genes such as cyclooxygenase-2 (COX-2). We examined the
molecular mechanisms by which the ... Cited by 8 - Related articles - All 3 versions
N Shanmugam, IT Todorov, I Nair, K Omori, MA Reddy, … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its
products, such as prostaglandin E 2 (PGE 2 ), have been implicated in the pathogenesis of several
inflammatory diseases including ... Cited by 13 - Related articles - BL Direct - All 3 versions
