- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A Barbeau, V … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion
(GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid
oxidation, thereby increasing the availability of LC-CoA for lipid signaling to cellular ... Cited by 89 - Related articles - BL Direct - All 7 versions
CJ Nolan, JL Leahy, V Delghingaro-Augusto, J Moibi, K … - Diabetologia, 2006 - Springer Page 1. ARTICLE Beta cell compensation for insulin resistance in Zucker fatty rats:
increased lipolysis and fatty acid signalling CJ Nolan & JL Leahy & V. Delghingaro-
Augusto & J. Moibi & K. Soni & M.-L. Peyot & M. Fortier & C. Guay & ... Cited by 44 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier, BE … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in hormone-sensitive
lipase-null mice (HSL −/− ), both in vivo and in vitro. The focus of the current study was to gain
further insight into the signaling role and regulation of lipolysis in islet tissue. The effect of ... Cited by 34 - Related articles - BL Direct - All 6 versions
L Herrero, B Rubí, D Sebastián, D Serra, G Asins, P … - Diabetes, 2005 - Am Diabetes Assoc Carnitine palmitoyltransferase I, which is expressed in the pancreas as the liver isoform
(LCPTI), catalyzes the rate-limiting step in the transport of fatty acids into the mitochondria for
their oxidation. Malonyl-CoA derived from glucose metabolism regulates fatty acid ... Cited by 26 - Related articles - All 7 versions
YQ Liu, TL Jetton, JL Leahy - Journal of Biological Chemistry, 2002 - ASBMB The β-cell biochemical mechanisms that account for the compensatory hyperfunction with insulin
resistance (so-calledβ-cell adaptation) are unknown. We investigated glucose metabolism in
isolated islets from 10–12-week-old Zucker fatty (ZF) and Zucker lean (ZL) rats (results ... Cited by 64 - Related articles - BL Direct - All 4 versions
H Mulder, S Yang, MS Winzell, C Holm, B Ahrén - Diabetes, 2004 - Am Diabetes Assoc Lipids may serve as coupling factors in K ATP -independent glucose sensing in β-cells. We have
previously demonstrated that β-cells harbor lipase activities, one of which is the hormone-sensitive
lipase. Whether β-cell lipases are critical for glucose-stimulated insulin secretion (GSIS) ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] B Rubí, PA Antinozzi, L Herrero, H Ishihara, … - Biochemical …, 2002 - pubmedcentral.nih.gov Lipid metabolism in the β-cell is critical for the regulation of insulin secretion. Pancreatic β-cells
chronically exposed to fatty acids show higher carnitine palmitoyltransferase I (CPT I) protein
levels, higher palmitate oxidation rates and an altered insulin response to glucose. We ... Cited by 42 - Related articles - BL Direct - All 8 versions
A Boucher, D Lu, SC Burgess, S Telemaque-Potts, … - Journal of Biological …, 2004 - ASBMB Hyperlipidemia appears to play an integral role in loss of glucose-stimulated insulin secretion
(GSIS) in type 2 diabetes. This impairment can be simulated in vitro by chronic culture of
832/13 insulinoma cells with high concentrations of free fatty acids, or by study of ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] S Farfari, V Schulz, B Corkey, M Prentki - Diabetes, 2000 - Am Diabetes Assoc The hypothesis proposing that anaplerosis and cata- plerosis play an important role in fuel signaling
by providing mitochondrially derived coupling factors for stimulation of insulin secretion was
tested. A rise in citrate coincided with the initiation of insulin secretion in response to ... Cited by 141 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] RL Dobbins, MW Chester, BE Stevenson, … - Journal of Clinical …, 1998 - pubmedcentral.nih.gov Lowering of the plasma FFA level in intact fasted rats by in- fusion of nicotinic acid (NA) caused
essentially complete ablation of insulin secretion (IS) in response to a subsequent intravenous
bolus of arginine, leucine, or glibenclamide (as previously found using glucose as the ... Cited by 88 - Related articles - BL Direct - All 9 versions
