- ►diabetesjournals.org L Massa, S Baltrusch, DA Okar, AJ Lange, S Lenzen, M … - Diabetes, 2004 - Am Diabetes Assoc The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
(PFK-2/FBPase-2) was recently identified as a new intracellular binding partner for glucokinase
(GK). Therefore, we studied the importance of this interaction for the activity status of GK ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►jbc.org S Baltrusch, S Lenzen, DA Okar, AJ Lange, M … - Journal of Biological …, 2001 - ASBMB The low affinity glucose-phosphorylating enzyme glucokinase shows the phenomenon of intracellular
translocation in beta cells of the pancreas and the liver. To identify potential binding partners
of glucokinase by a systematic strategy, human beta cell glucokinase was screened by a ... Cited by 46 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org VA Payne, C Arden, C Wu, AJ Lange, L Agius - Diabetes, 2005 - Am Diabetes Assoc Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is both an inhibitor
and nuclear receptor for glucokinase. We tested the role of 6-phosphofructo-2-kinase/fructose
-2,6-bisphosphatase (PFK2) in regulating glucokinase compartmentation in hepatocytes. ... Cited by 29 - Related articles - All 5 versions
S Baltrusch, F Francini, S Lenzen, M Tiedge - Diabetes, 2005 - Am Diabetes Assoc The glucokinase regulatory protein (GRP) plays a pivotal role in the regulation of metabolic flux
in liver by the glucose-phosphorylating enzyme glucokinase. Random peptide phage display
library screening for binding partners of GRP allowed the identification of an asparagine- ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org C Arden, A Trainer, N de la Iglesia, KT Scougall, AL … - Diabetes, 2007 - Am Diabetes Assoc Mutations in the glucokinase (GK) gene cause defects in blood glucose homeostasis. In some
cases (V62M and G72R), the phenotype cannot be explained by altered enzyme kinetics or protein
instability. We used transient and stable expression of green fluorescent protein (GFP) GK ... Cited by 7 - Related articles - BL Direct - All 4 versions
C Arden, A Harbottle, S Baltrusch, M Tiedge, L Agius - Diabetes, 2004 - Am Diabetes Assoc The association of glucokinase with insulin secretory granules has been shown by cell microscopy
techniques. We used MIN6 insulin-secretory cells and organelle fractionation to determine the
effects of glucose on the subcellular distribution of glucokinase. After permeabilization ... Cited by 27 - Related articles - BL Direct - All 4 versions
PT Burch, DK Berner, H Najafi, MD Meglasson, FM … - Diabetes, 1985 - Am Diabetes Assoc Fructose-2,6-P2 was measured in perifused, isolated rat pancreatic islets. Fructose-2,6-P2 was
present in pancreatic islets at low levels approximately equal to fructose-2,6-P2 content of liver
from fasted rats. In islets perifused with glucose at physiologic concentrations, ... Cited by 13 - Related articles - All 4 versions
A Shiraishi, Y Yamada, Y Tsuura, S Fijimoto, K … - Journal of Biological …, 2001 - ASBMB A glucokinase regulatory protein has been reported to exist in the liver, which suppresses enzyme
activity in a complex with fructose 6-phosphate, whereas no corresponding protein has been
found in pancreatic cells. To search for such a protein in pancreatic cells, we screened for ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org S Baltrusch, M Tiedge - Diabetes, 2006 - Am Diabetes Assoc The low-affinity glucose-phosphorylating enzyme glucokinase (GK) is the flux-limiting glucose
sensor in liver and β-cells of the pancreas. Furthermore, GK is also expressed in various neuroendocrine
cell types. This review describes the complex network of GK regulation, which shows ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] A Sener, E Van Schaftingen, M Van de … - Biochemical …, 1984 - pubmedcentral.nih.gov Glucose caused a sustained and dose-related increase in the fructose 2,6-bisphosphate cpntent
of isolated pancreatic islets, as well as of purified pancreatic B-cells. With isolated B-cells, the
glucose saturation curve was sigmoidal and superimposable on that obtained with ... Cited by 20 - Related articles - All 4 versions
