- ►diabetesjournals.org B Brunmair, K Staniek, F Gras, N Scharf, A … - Diabetes, 2004 - Am Diabetes Assoc Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic
effects via different mechanisms. As evidence suggests that both impair cell
respiration in vitro, this study compared their effects on mitochondrial ... Cited by 110 - Related articles - BL Direct - All 5 versions
A Actions - DIABETES, 2004 - Am Diabetes Assoc Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic
effects via different mecha- nisms. As evidence suggests that both impair cell
respi- ration in vitro, this study compared their effects on mitochondrial ... Related articles
MY El-Mir, V Nogueira, E Fontaine, N Avéret, … - Journal of Biological Chemistry, 2000 - ASBMB We report here a new mitochondrial regulation occurring only in intact cells. We
have investigated the effects of dimethylbiguanide on isolated rat hepatocytes,
permeabilized hepatocytes, and isolated liver mitochondria. Addition of ... Cited by 137 - Related articles - BL Direct - All 3 versions
- ►nih.gov [PDF] MR Owen, E Doran, AP Halestrap - Biochemical Journal, 2000 - pubmedcentral.nih.gov Although metformin is widely used for the treatment of non- insulin-dependent
diabetes, its mode of action remains unclear. Here we provide evidence that its
primary site of action is through a direct inhibition of complex 1 of the ... Cited by 224 - Related articles - BL Direct - All 7 versions
R Scatena, P Bottoni, GE Martorana, F Ferrari … - Biochemical and Biophysical Research …, 2004 - Elsevier Peroxisome proliferator activated receptors (PPARs) are a class of nuclear
receptors involved in lipid and glucidic metabolism, immune regulation, and cell
differentiation. Many of their biological activities have been studied by ... Cited by 38 - Related articles - All 4 versions
PK Narayanan, T Hart, F Elcock, C Zhang, L … - Cytometry Part A, 2003 - interscience.wiley.com Troglitazone (TRO), a thiazolidinedione (TZD) peroxisome proliferator-activated
receptor agonist, was recently withdrawn from the market because of rare but
serious hepatotoxicity. Previous studies investigating the cytotoxicity of ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►physiology.org JR Colca, WG McDonald, DJ Waldon, JW … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Thiazolidinediones address underlying causes of type 2 diabetes, although their
mechanism of action is not clearly understood. The compounds are thought to
function as direct activators of the nuclear receptor PPAR (peroxisome ... Cited by 42 - Related articles - BL Direct - All 4 versions
B Guigas, D Detaille, C Chauvin, C Batandier … - Biochemical Journal, 2004 - pubmedcentral.nih.gov Metformin, a drug widely used in the treatment of Type II diabetes, has recently
received attention owing to new findings regarding its mitochondrial and
cellular effects. In the present study, the effects of metformin on ... Cited by 34 - Related articles - BL Direct - All 8 versions
DL Feinstein, A Spagnolo, C Akar, G … - Biochemical Pharmacology, 2005 - Elsevier Agonists of the peroxisome proliferator activated receptor gamma (PPARγ) are
currently used for treatment of type 2 diabetes due to their insulin sensitizing
and glucose metabolism stabilizing effects. More recently some of these ... Cited by 127 - Related articles - All 4 versions
AK Saha, PR Avilucea, JM Ye, MM Assifi, … - Biochemical and Biophysical Research …, 2004 - Elsevier Thiazolidinediones have been shown to activate AMP-activated protein kinase
activity in cultured cells. Whether they have a similar effect in vivo and if so
whether it is physiologically relevant is not known. To assess these ... Cited by 103 - Related articles - All 4 versions
