- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is
elevated in various insulin-resistant states including type 2 diabetes, obesity,
cancer, and HIV-associated lipodystrophy. To determine the role of IL-6 in ... Cited by 166 - Related articles - BL Direct - All 4 versions
PJ Klover, TA Zimmers, LG Koniaris, RA … - Diabetes, 2003 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines associated with
the insulin resistance of obesity and type 2 diabetes. There is, however, little
direct evidence in vivo for a causative role of IL-6 in insulin resistance. ... Cited by 165 - Related articles - BL Direct - All 4 versions
AL Carey, GR Steinberg, SL Macaulay, WG … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance,
little is known regarding the effects of IL-6 on insulin sensitivity in humans
in vivo. Here, we show that IL-6 infusion increases glucose disposal ... Cited by 99 - Related articles - BL Direct - All 6 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in
part because circulating IL-6 is elevated. Exogenous IL-6 can induce hepatic
insulin resistance in vitro and in vivo. The importance of endogenous IL-6, ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►jbc.org V Rotter, I Nagaev, U Smith - Journal of Biological Chemistry, 2003 - ASBMB Several studies have shown a relationship between interleukin (IL) 6 levels and
insulin resistance. We here show that human subcutaneous adipose cells, like
3T3-L1 cells, are target cells for IL-6. To examine putative mechanisms and ... Cited by 278 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JJ Senn, PJ Klover, IA Nowak, RA Mooney - Diabetes, 2002 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines that have been
associated with insulin resistance and type 2 diabetes. A two- to threefold
elevation of circulating IL-6 has been observed in these conditions. ... Cited by 316 - Related articles - BL Direct - All 6 versions
JJ Senn, PJ Klover, IA Nowak, TA Zimmers, … - Journal of Biological Chemistry, 2003 - ASBMB Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines implicated in
insulin resistance during infection, cachexia, and obesity. We recently
demonstrated that IL-6 inhibits insulin signaling in hepatocytes (Senn, JJ, ... Cited by 274 - Related articles - BL Direct - All 9 versions
- ►physiology.org C Weigert, AM Hennige, K Brodbeck, HU … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Previous studies showed an insulin-"desensitizing" action of IL-6 on glycogen
synthesis in hepatocytes. We recently found no inhibition of the proximal steps
of the insulin signal cascade in human skeletal muscle cells. Because these ... Cited by 46 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MA Febbraio, N Hiscock, M Sacchetti, CP … - Diabetes, 2004 - Am Diabetes Assoc The mechanisms that mediate the tightly controlled production and clearance of
glucose during muscular work are unclear, and it has been suggested that an
unidentified “work factor” exists that influences the ... Cited by 84 - Related articles - BL Direct - All 5 versions
- ►physiology.org CR Bruce, DJ Dyck - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc IL-6 and TNF- have been associated with insulin resistance and type 2 diabetes.
Furthermore, abnormalities in muscle fatty acid (FA) metabolism are strongly
associated with the development of insulin resistance. However, few studies ... Cited by 55 - Related articles - BL Direct - All 4 versions
