K Skak, CF Gotfredsen, D Lundsgaard, JB … - Diabetes, 2004 - Am Diabetes Assoc Treatment with ATP-sensitive K + channel openers (KCOs) leads to inhibition of
insulin secretion and metabolic “rest” in β-cells. It is hypothesized that
in type 1 diabetes this may reduce β-cell death resulting from metabolic ... Cited by 25 - Related articles - BL Direct - All 4 versions
RD Carr, CL Brand, TB Bodvarsdottir, JB … - Diabetes, 2003 - Am Diabetes Assoc A novel potassium channel opener compound, NN414, selective for the SUR1/Kir6.2
subtype of the ATP-sensitive potassium channel, was used to examine the effect
of reducing β-cell workload in the male Vancouver diabetic fatty (VDF) ... Cited by 30 - Related articles - BL Direct - All 4 versions
K Skak, CF Gotfredsen, D Lundsgaard, JB … - Diabetes, 2004 - Am Diabetes Assoc Treatment with ATP-sensitive K channel openers (KCOs) leads to inhibition of
insulin secretion and metabolic “rest” in -cells. It is hypothesized that in
type 1 diabetes this may reduce -cell death resulting from metabolic stress ... Cited by 6 - Related articles
M Guldstrand, V Grill, A Björklund, PE Lins, … - Diabetes & metabolism, 2002 - cat.inist.fr Objectif: Notre but était de distinguer les effets bénéfiques de la mise au
repos des cellules bêta des autres effets de la correction de l'hyperglycémie.
Pour cela nous avons utilisé le diazoxide qui bloque de façon réversible ... Cited by 40 - Related articles - BL Direct - All 3 versions
- ►endojournals.org RA Ritzel, JB Hansen, JD Veldhuis, PC Butler - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc In health, most insulin is secreted in pulses. Type 2 diabetes mellitus (TTDM)
is characterized by impaired pulsatile insulin secretion with a defect in
insulin pulse mass. It has been suggested that this defect is partly due to ... Cited by 35 - Related articles - BL Direct - All 5 versions
SB Rasmussen, TS Sørensen, JB Hansen, T … - Hormone and metabolic research. Hormon-und …, 2000 - ncbi.nlm.nih.gov Diazoxide and the diazoxide-analogue, NNC 55-0118, are potassium channel openers
that interfere with insulin secretion from beta-cells. In vitro, we show that
these two drugs inhibit insulin release from diabetes-resistant BB rat ... Cited by 31 - Related articles - BL Direct - All 3 versions
M Matsuda, F Kawasaki, Y Mikami, Y Takeuchi … - European journal of pharmacology, 2002 - Elsevier In this study, we attempted to demonstrate the possibility of rescuing beta-cell
exhaustion by chronic intervention with an ATP-sensitive K + channel opener,
diazoxide, which reduces the stress of insulin secretion, using rats with ... Cited by 16 - Related articles - All 4 versions
JB Hansen, GA PO, TB Bodvarsdottir, P Wahl - Current Medicinal Chemistry, 2004 - ingentaconnect.com Abstract: The pattern of insulin release is crucial for regulation of glucose
and lipid haemostasis. Deficient insulin release causes hyperglycemia and
diabetes, whereas excessive insulin release can give rise to serious ... Cited by 25 - Related articles - BL Direct - All 2 versions
R Alemzadeh, C Fledelius, T Bodvarsdottir, J … - Metabolism, 2004 - Elsevier Chronic attenuation of hyperinsulinemia by diazoxide (DZ), a K-adenosine
triphosphate (ATP) channel opener and an inhibitor of glucose-mediated insulin
secretion, improved glucose tolerance and lipid profile and decreased the ... Cited by 12 - Related articles - All 8 versions
FE Nielsen, TB Bodvarsdottir, A Worsaae, P … - J. Med. Chem, 2002 - pubs.acs.org 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives
were synthesized and characterized as activators of adenosine 5'-triphosphate
(ATP) sensitive potassium (K ATP ) channels in the β-cells by measuring ... Cited by 33 - Related articles - BL Direct - All 4 versions
