D Duran-Sandoval, G Mautino, G Martin, F Percevault, … - Diabetes, 2004 - Am Diabetes Assoc An increased prevalence of hypertriglyceridemia and gallbladder disease occurs in patients
with diabetes or insulin resistance. Hypertriglyceridemia is positively associated to gall bladder
disease risk. The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor that ... Cited by 67 - Related articles - BL Direct - All 4 versions
- ►endojournals.org KR Stayrook, KS Bramlett, RS Savkur, J Ficorilli, T … - Endocrinology, 2005 - Endocrine Soc The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that functions as the bile
acid receptor. In addition to the critical role FXR plays in bile acid metabolism and transport, it
regulates a variety of genes important in lipoprotein metabolism. We demonstrate that ... Cited by 67 - Related articles - All 5 versions
K Yamagata, H Daitoku, Y Shimamoto, H Matsuzaki … - Journal of Biological …, 2004 - ASBMB Bile acid homeostasis is tightly controlled by the feedback mechanism in which an atypical orphan
nuclear receptor (NR) small heterodimer partner (SHP) inactivates several NRs such as liver
receptor homologue-1 and hepatocyte nuclear factor 4. Although NRs have been ... Cited by 67 - Related articles - BL Direct - All 4 versions
B Cariou, K van Harmelen, D Duran-Sandoval, T van … - FEBS letters, 2005 - Elsevier The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine
whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR −/− ) and wild-type
mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the ... Cited by 22 - Related articles - All 4 versions
- ►nih.gov K Ma, PK Saha, L Chan, DD Moore - Journal of Clinical …, 2006 - Am Soc Clin Investig The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and
lipid metabolism. We show here that FXR plays a key regulatory role in glucose
homeostasis. FXR-null mice developed severe fatty liver and elevated circulating FFAs, ... Cited by 113 - Related articles - BL Direct - All 9 versions
- ►jbc.org D Duran-Sandoval, B Cariou, F Percevault, N … - Journal of Biological …, 2005 - ASBMB The liver plays a central role in the control of blood glucose homeostasis by maintaining a balance
between glucose production and utilization. The farnesoid X receptor (FXR) is a bile acid-activated
nuclear receptor. Hepatic FXR expression is regulated by glucose and insulin. Here we ... Cited by 35 - Related articles - BL Direct - All 5 versions
B Cariou, K van Harmelen, D Duran-Sandoval, TH … - Journal of Biological …, 2006 - ASBMB The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a major
role in the regulation of BA and lipid metabolism. Recently, several studies have suggested a
potential role of FXR in the control of hepatic carbohydrate metabolism, but its ... Cited by 69 - Related articles - BL Direct - All 7 versions
Y Zhang, FY Lee, G Barrera, H Lee, C … - Proceedings of the …, 2006 - National Acad Sciences Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol
homeostasis. Here we demonstrate that FXR also regulates glucose metabolism. Activation of
FXR by the synthetic agonist GW4064 or hepatic overexpression of constitutively active ... Cited by 115 - Related articles - BL Direct - All 10 versions
- ►jbc.org E De Fabiani, N Mitro, F Gilardi, D Caruso, G Galli, … - Journal of Biological …, 2003 - ASBMB Bile acid metabolism plays an essential role in cholesterol homeostasis and is critical for the
initiation of atherosclerotic disease. However, despite the recent advances, the molecular mechanisms
whereby bile acids regulate gene transcription and cholesterol homeostasis in mammals ... Cited by 95 - Related articles - BL Direct - All 5 versions
Y Zhang, LW Castellani, CJ Sinal, FJ … - Genes & …, 2004 - genesdev.cshlp.org Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) has been shown to regulate
adaptive thermogenesis and glucose metabolism. Here we show that PGC-1α regulates triglyceride
metabolism through both farnesoid X receptor (FXR)-dependent and -independent ... Cited by 112 - Related articles - BL Direct - All 7 versions
