HS Kwon, B Huang, TG Unterman, RA Harris - Diabetes, 2004 - Am Diabetes Assoc Starvation and diabetes increase pyruvate dehydrogenase kinase-4 (PDK4) expression, which
conserves gluconeogenic substrates by inactivating the pyruvate dehydrogenase complex. Mechanisms
that regulate PDK4 gene expression, previously established to be increased by ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] T Furuyama, K Kitayama, H Yamashita, N … - Biochemical …, 2003 - pubmedcentral.nih.gov A forkhead-type transcription factor, DAF-16, is located in the most downstream part of the insulin
signalling pathway via PI3K (phosphoinositide 3-kinase). It is essential for the extension of
life-span and is also involved in dauer formation induced by food deprivation in ... Cited by 95 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org B Huang, P Wu, MM Bowker-Kinley, RA Harris - Diabetes, 2002 - Am Diabetes Assoc Pyruvate dehydrogenase kinase (PDK) catalyzes phosphorylation and inactivation of the pyruvate
dehydrogenase complex (PDC). Two isoforms of this mitochondrial kinase (PDK2 and
PDK4) are induced in a tissue-specific manner in response to starvation and diabetes. ... Cited by 84 - Related articles - BL Direct - All 5 versions
RA Harris, MM Bowker-Kinley, B Huang, P Wu - Advances in enzyme regulation, 2002 - Elsevier The pyruvate dehydrogenase complex catalyzes the irreversible oxidative decarboxylation of
pyruvate to form acetyl-CoA. This reaction links glycolysis and the citric acid cycle in every cell
containing mitochondria. The activated two-carbon acetyl unit can also be used for fatty ... Cited by 57 - Related articles - BL Direct - All 3 versions
- ►jbc.org K Ma, Y Zhang, MB Elam, GA Cook, EA Park - Journal of Biological Chemistry, 2005 - ASBMB The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-CoA in
mitochondria and is a key regulatory enzyme in the metabolism of glucose to acetyl-CoA. Phosphorylation
of pyruvate dehydrogenase by the pyruvate dehydrogenase kinases (PDK) inhibits ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] MJ Holness, A Kraus, RA Harris, MC Sugden - Diabetes, 2000 - Am Diabetes Assoc Page 1. DIABETES, VOL. 49, MAY 2000 775 Targeted Upregulation of Pyruvate
Dehydrogenase Kinase (PDK)-4 in Slow-Twitch Skeletal Muscle Underlies the Stable
Modification of the Regulatory Characteristics of PDK Induced by High-Fat Feeding ... Cited by 75 - Related articles - BL Direct - All 6 versions
- ►physiology.org MC Sugden, MJ Holness - American Journal of Physiology- …, 2003 - Am Physiological Soc The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation
of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid (FA) synthesis. Knowledge
of the mechanisms that regulate PDC activity is important, because PDC inactivation is ... Cited by 100 - Related articles - BL Direct - All 3 versions
HS Kwon, RA Harris - Advances in enzyme regulation, 2004 - Elsevier The pyruvate dehydrogenase (PDH) complex (EC 1.2.4.1; EC 2.3.2.12; EC 1.8.1.4) catalyzes
the oxidation of pyruvate to acetyl-CoA in mammalian cells containing mitochondria. In the
well-fed state, PDH is relatively active to generate acetyl-CoA that is used for fatty acid ... Cited by 20 - Related articles - All 4 versions
- ►nih.gov AR Wende, JM Huss, PJ Schaeffer, V Giguere … - Molecular and Cellular …, 2005 - Am Soc Microbiol The transcriptional coactivator PGC-1 is a key regulator of energy metabolism, yet little is known
about its role in control of substrate selection. We found that physiological stimuli known to induce
PGC-1 expression in skeletal muscle coordinately upregulate the expression of pyruvate ... Cited by 93 - Related articles - All 5 versions
M Araki, K Motojima… - FEBS J, 2006 - interscience.wiley.com Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulatory enzyme involved in switching the
energy source from glucose to fatty acids in response to physiological conditions. Transcription
of the PDK4 gene is activated by fasting or by the administration of a PPARα ligand in a ... Cited by 24 - Related articles - BL Direct - All 6 versions
