- ►diabetesjournals.org EB Arias, J Kim, GD Cartee - Diabetes, 2004 - Am Diabetes Assoc Increased flux through the hexosamine biosynthetic pathway and increased O-linked glycosylation
(N-acetylglucosamine [O-GlcNAc]) of proteins have been implicated in insulin resistance. Previous
research in 3T3-L1 adipocytes indicated that insulin-stimulated glucose uptake and ... Cited by 46 - Related articles - BL Direct - All 7 versions
SY Park, J Ryu, W Lee - Exp Mol Med, 2005 - e-emm.or.kr 1From the Department of Biochemistry College of Medicine, Dongguk University Gyeongju
780-714, Korea 2Biophysics Laboratory Veteran Affairs Medical Center Department of Physiology
and Biophysics School of Medicine, State University of New York at Buffalo Buffalo, NY ... Cited by 35 - Related articles - View as HTML - All 13 versions
K Vosseller, L Wells, MD Lane, GW … - Proceedings of the …, 2002 - National Acad Sciences Increased flux of glucose through the hexosamine biosynthetic pathway (HSP) is believed to
mediate hyperglycemia-induced insulin resistance in diabetes. The end product of the HSP,
UDPβ-N-acetylglucosamine (GlcNAc), is a donor sugar nucleotide for complex ... Cited by 182 - Related articles - BL Direct - All 8 versions
Y Gao, GJ Parker, GW Hart - Archives of Biochemistry and Biophysics, 2000 - Elsevier Streptozotocin (STZ) injection into experimental animals selectively causes massive β-cell
death. The mechanism of this specific toxicity is not fully understood. Recently, it has been discovered
that O-linked N-acetylglucosamine (O-GlcNAc) is enriched in the β-cells. It has been ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►pnas.org DA McClain, WA Lubas, RC Cooksey, M … - Proceedings of the …, 2002 - National Acad Sciences Insulin resistance and β cell toxicity are key features of type 2 diabetes. One leading hypothesis
suggests that these abnormalities result from excessive flux of nutrients through the UDP–hexosamine
biosynthetic pathway leading to “glucose toxicity.” How the products of the hexosamine ... Cited by 103 - Related articles - BL Direct - All 10 versions
- ►physiology.org JLE Walgren, TS Vincent, KL Schey, … - American Journal of …, 2003 - Am Physiological Soc Increased flux through the hexosamine biosynthesis pathway has been implicated in the development
of glucose-induced insulin resistance and may promote the modification of certain proteins with
O-linked N-acetylglucosamine (O-GlcNAc). L6 myotubes (a model of skeletal muscle) ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►physiology.org KA Robinson, LE Ball, MG Buse - American Journal of Physiology …, 2007 - Am Physiological Soc 3T3-L1 adipocytes develop insulin-resistant glucose transport upon preincubation with high
(25 mM) glucose, provided that insulin (0.6 nM) is included, Akt activation is impaired, and high
glucose and insulin act synergistically. Considerable evidence suggests that increased ... Cited by 10 - Related articles - BL Direct - All 6 versions
MD Roos, W Xie, K Su, JA Clark, X Yang, E Chin, … - Proceedings of the … - ncbi.nlm.nih.gov Streptozotocin (STZ), an analog of N-acetylglucosamine (GlcNAc), is a specific toxin for the pancreatic
beta cell. We found that treatment of rats with STZ results in an early beta-cell-specific increase
in the level of intracellular protein modification by O-linked GlcNAc (O-GlcNAc). Using a ... Cited by 69 - Related articles - BL Direct - All 3 versions
G Parker, R Taylor, D Jones, D McClain - Journal of Biological Chemistry, 2004 - ASBMB Glycogen synthase is post-translationally modified by both phosphate and O-linked N-acetylglucosamine
(O-GlcNAc). In 3T3-L1 adipocytes exposed to high concentrations of glucose, O-GlcNAc contributes
to insulin resistance of glycogen synthase. We sought to determine whether O-GlcNAc ... Cited by 34 - Related articles - BL Direct - All 4 versions
N Comtesse, E Maldener, E Meese - Biochemical and Biophysical Research …, 2001 - Elsevier MGEA5 was originally identified to be a novel human hyaluronidase, which is immunogenic
in meningioma patients. Recently an N-acetylglucosaminidase was reported with identical
sequence. Here, we define the origin of a splice variant by determining the genomic ... Cited by 35 - Related articles - BL Direct - All 5 versions
