- ►diabetesjournals.org NM Morton, JM Paterson, H Masuzaki, MC … - Diabetes, 2004 - Am Diabetes Assoc The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes,
and dyslipidemia) resembles Cushing's Syndrome, but without elevated circulating
glucocorticoid levels. An emerging concept suggests that the aberrantly ... Cited by 191 - Related articles - BL Direct - All 4 versions
- ►nih.gov JM Paterson, NM Morton, C Fievet, CJ Kenyon, … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences In obese humans and rodents there is increased expression of the key
glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type
1 (11β-HSD1), in adipose tissue. This increased expression appears to be ... Cited by 144 - Related articles - BL Direct - All 10 versions
NM Morton, MC Holmes, C Fievet, B Staels, A … - Journal of Biological Chemistry, 2001 - ASBMB Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin
resistance, and impaired glucose tolerance of the metabolic syndrome.
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD-1) catalyzes conversion ... Cited by 213 - Related articles - BL Direct - All 3 versions
- ►endojournals.org K Kannisto, KH Pietilainen, E Ehrenborg, A … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) catalyzes the
interconversion of inactive cortisone to active cortisol. Overexpression of
11ß-HSD-1 in murine adipose tissue results in glucocorticoid receptor (GR) ... Cited by 104 - Related articles - BL Direct - All 7 versions
- ►nih.gov H Masuzaki, H Yamamoto, CJ Kenyon, JK … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Obesity is closely associated with the metabolic syndrome, a combination of
disorders including insulin resistance, diabetes, dyslipidemia, and
hypertension. A role for local glucocorticoid reamplification in obesity ... Cited by 215 - Related articles - BL Direct - All 6 versions
- ►pnas.org Y Kotelevtsev, MC Holmes, A Burchell, PM … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic
processes, including hepatic gluconeogenesis. It recently has been recognized
that intracellular glucocorticoid concentrations are determined not only by ... Cited by 381 - Related articles - BL Direct - All 11 versions
- ►endojournals.org P Alberts, C Nilsson, G Selen, LOM Engblom, … - Endocrinology, 2003 - Endocrine Soc IT IS WELL established that glucocorticoids oppose the insulin effect in
regulation of carbohydrate metabolism in vivo, including glucose uptake in
peripheral tissues and hepatic glucose production (1). The liver plays a ... Cited by 151 - Related articles - BL Direct - All 4 versions
- ►endojournals.org O Paulmyer-Lacroix, S Boullu, C Oliver, MC … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Glucocorticoids play an important role in determining adipose tissue metabolism
and distribution. Patients with Cushing's syndrome or receiving corticosteroid
therapy develop a reversible visceral obesity. In obese patients, although ... Cited by 156 - Related articles - BL Direct - All 4 versions
P Alberts, L Engblom, N Edling, M Forsgren, G … - Diabetologia, 2002 - Springer Aims/hypothesis. Current pharmacological treatments for Type II
(non-insulin-dependent) diabetes mellitus have various limitations. New
treatments are needed to reduce long-term risks for diabetic complications ... Cited by 158 - Related articles - BL Direct - All 3 versions
- ►rupress.org A Hermanowski-Vosatka, JM Balkovec, K Cheng … - Journal of Experimental Medicine, 2005 - jem.rupress.org The enzyme 11ß–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive
cortisone into active cortisol in cells, thereby raising the effective
glucocorticoid (GC) tone above serum levels. We report that pharmacologic ... Cited by 121 - Related articles - BL Direct - All 8 versions
