C Tikellis, PJ Wookey, R Candido, S Andrikopoulos, … - Diabetes, 2004 - Am Diabetes Assoc The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Although
angiotensin II has significant effects on cell proliferation and apoptosis, the contribution of the
RAS to changes in islet structure and function associated with type 2 diabetes is yet to be ... Cited by 122 - Related articles - BL Direct - All 6 versions
T Lau, PO Carlsson, PS Leung - Diabetologia, 2004 - Springer Aims/hypothesis. A local angiotensin-generating system has been found in the exocrine
pancreas. This study aimed, primarily, to investigate the existence of a local angiotensin-generating
system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin ... Cited by 71 - Related articles - BL Direct - All 9 versions
SH Ko, HS Kwon, SR Kim, SD Moon, YB Ahn, KH … - … and biophysical research …, 2004 - Elsevier We evaluated whether ramipril, one of long-acting ACEIs, has a direct effect on pancreas islets
in animal model of type 2 diabetes. OLETF rats were treated with ramipril for 24 weeks. We assessed
the body weight, glucose tolerance, and the amount of islet fibrosis. RT-PCR and Western ... Cited by 42 - Related articles - All 8 versions
PO Carlsson, C Berne, L Jansson - Diabetologia, 1998 - Springer Summary An intrinsic angiotensin system has been described in the pancreas, with angiotensin
II specific receptors being present on both exocrine, endocrine and vascular cells. The aim of
the present study was to evaluate the effects of angiotensin II on insulin se- cretion and ... Cited by 162 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] M Tahmasebi, JR Puddefoot, ER Inwang, … - Journal of …, 1999 - Soc Endocrinology Evidence exists for the presence of a discrete tissue renin–angiotensin system (RAS) in mouse
and rat pancreas that is thought largely to be associated with the vascu- lature. To investigate
this in the human pancreas, and to establish whether the cellular sites of RAS ... Cited by 92 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org KY Chu, T Lau, PO Carlsson, PS Leung - Diabetes, 2006 - Am Diabetes Assoc We identified an angiotensin-generating system in pancreatic islets and found that exogenously
administered angiotensin II, after binding to its receptors (angiotensin II type 1 receptor
[AT1R]), inhibits insulin release in a manner associated with decreased islet blood flow ... Cited by 57 - Related articles - BL Direct - All 9 versions
PS Leung, PO Carlsson - Pancreas, 2005 - journals.lww.com Supported by the Mainline Research Scheme from the Chinese University of Hong Kong
(MR00/008) and partially by the Research Grants Council of Hong Kong (CUHK 4075/00M, CUHK
4116/01M, and CUHK4364/04M), the Swedish Research Council (72XD-15043), the ... Cited by 38 - Related articles - All 6 versions
J Shao, N Iwashita, F Ikeda, T Ogihara, T Uchida, T … - … and biophysical research …, 2006 - Elsevier Several epidemiological studies suggested that treatment with angiotensin II type 1 receptor
blocker (ARB) provided a risk reduction of developing type 2 diabetes. In this study, we investigated
whether and how ARB treatment can improve abnormalities of pancreatic islets in ... Cited by 34 - Related articles - All 6 versions
M Nakayama, T Inoguchi, T Sonta, Y Maeda, S … - … and Biophysical Research …, 2005 - Elsevier This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress
in islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of
NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets ... Cited by 42 - Related articles - All 6 versions
HR Oliveira, R Verlengia, CRO Carvalho, LRG Britto, R … - Diabetes, 2003 - Am Diabetes Assoc The presence of a phagocyte-like NAD(P)H oxidase in pancreatic β-cells was investigated. Three
NAD(P)H oxidase components were found in pancreatic islets by RT-PCR: gp91 PHOX , p22
PHOX , and p47 PHOX . The components p67 PHOX and p47 PHOX were also ... Cited by 58 - Related articles - BL Direct - All 4 versions
