S Uehara, A Muroyama, N Echigo, R Morimoto, M … - Diabetes, 2004 - Am Diabetes Assoc In islets of Langerhans, l-glutamate is stored in glucagon-containing secretory granules of
α-cells and cosecreted with glucagon under low-glucose conditions. The l-glutamate triggers
secretion of γ-aminobutyric acid (GABA) from β-cells, which in turn inhibits glucagon ... Cited by 25 - Related articles - BL Direct - All 5 versions
A Muroyama, S Uehara, S Yatsushiro, N Echigo, R … - Diabetes, 2004 - Am Diabetes Assoc Many metabolic factors affect the secretion of insulin from β-cells and glucagon from α-cells of
the islets of Langerhans to regulate blood glucose. Somatostatin from δ-cells, considered a local
inhibitor of islet function, reduces insulin and glucagon secretion by activating ... Cited by 9 - Related articles - BL Direct - All 7 versions
- ►cell.com Y Moriyama, M Hayashi - Trends in pharmacological sciences, 2003 - Elsevier Increasing evidence suggests that the excitatory neurotransmitter -glutamate functions as a modulator
in the islet of Langerhans, an endocrine organ involved in blood glucose homeostasis. The islet
is equipped with all the elements required for -glutamate-mediated transmission, and it ... Cited by 21 - Related articles - All 8 versions
- ►jbc.org M Hayashi, H Yamada, S Uehara, R Morimoto, A … - Journal of Biological …, 2003 - ASBMB L-Glutamate is believed to function as an intercellular transmitter in the islets of Langerhans.
However, critical issues, ie where, when and how L-glutamate appears, and what happens upon
stimulation of glutamate receptors in the islets, remain unresolved. Vesicular glutamate ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org H Yamada, M Otsuka, M Hayashi, S Nakatsuka, K … - Diabetes, 2001 - Am Diabetes Assoc Pancreatic islet cells express receptors and transporters for L-glutamate and are thus believed
to use L-glutamate as an intercellular signaling molecule. However, the mechanism by which
L-glutamate appears in the islets is unknown. In the present study, we investigated ... Cited by 22 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org M Storto, L Capobianco, G Battaglia, G Molinaro, R … - Molecular pharmacology, 2006 - ASPET Recent evidence suggests that metabotropic glutamate (mGlu) receptors are involved in the
regulation of hormone secretion in the endocrine pancreas. We report here that endogenous
activation of mGlu5 receptors is required for an optimal insulin response to glucose both ... Cited by 11 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Hayashi, M Otsuka, R Morimoto, A Muroyama, S … - Diabetes, 2003 - Am Diabetes Assoc Islets of Langerhans contain γ-aminobutyrate (GABA) and may use it as an intercellular
transmitter. In β-cells, GABA is stored in synaptic-like microvesicles and secreted through Ca
2+ -dependent exocytosis. Vesicular inhibitory amino acid transporter (VIAAT), which is ... Cited by 13 - Related articles - BL Direct - All 5 versions
S Uehara, SK Jung, R Morimoto, S Arioka, … - Journal of …, 2006 - interscience.wiley.com Vesicular glutamate transporter (VGLUT) is responsible for the vesicular storage of
l-glutamate, and plays an essential role in glutamate-mediated intercellular signal transmission
in the CNS and in some neuroendocrine cells. Intestinal L cells are the ... Cited by 6 - Related articles - BL Direct - All 5 versions
H Zhou, POT Tran, S Yang, T Zhang, E LeRoy, E Oseid, … - Diabetes, 2004 - Am Diabetes Assoc The glucagon response is the first line of defense against hypoglycemia and is lost in
insulin-dependent diabetes. The ß-cell "switch-off" hypothesis proposes that a sudden cessation
of insulin secretion from ß-cells into the portal circulation of the islet during hypoglycemia ... Cited by 39 - Related articles - BL Direct - All 4 versions
KM Hope, POT Tran, H Zhou, E Oseid, E Leroy, RP … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell function during hypoglycemia
has not been assessed previously in isolated islets, largely because they characteristically do
not respond to glucose deprivation by secreting glucagon. We examined this hypothesis ... Cited by 43 - Related articles - BL Direct - All 4 versions
