M Straczkowski, I Kowalska, A Nikolajuk, S … - Diabetes, 2004 - Am Diabetes Assoc In vitro studies revealed that insulin resistance might be associated with the
intracellular formation of ceramide, the second messenger in the sphingomyelin
signaling pathway. The aim of the present study was to examine the content ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in
insulin resistance, but the precise nature of the lipid species that produce
insulin resistance in human muscle are unknown. Ceramides, either generated ... Cited by 117 - Related articles - BL Direct - All 9 versions
M Gorska, A Dobrzyń, M Zendzian-Piotrowska, … - Hormone and metabolic research. Hormon-und …, 2004 - ncbi.nlm.nih.gov AIMS/HYPOTHESIS: Ceramide is the main second messenger in the
sphingomyelin-transmembrane signalling pathway. The compound is likely to play a
role in the induction of insulin resistance. The aim of the present study ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►jbc.org [PDF] J Turinsky, DM O'sullivan, BP Bayly - Journal of Biological Chemistry, 1990 - ASBMB Diacylglycerol and Ceramides in Rat Tissues in Vivo 16881 observed in isolated
muscles or perfused hindquarters of obese rats (14-16). The second series of
experiments was performed on normal Sprague-Dawley rats and investigated ... Cited by 100 - Related articles - All 3 versions
- ►jbc.org S Stratford, KL Hoehn, F Liu, SA Summers - Journal of Biological Chemistry, 2004 - ASBMB The sphingolipid ceramide negatively regulates insulin action by inhibiting
Akt/protein kinase B (PKB), a serine/threonine kinase that is a central
regulator of glucose uptake and anabolic metabolism. Despite considerable ... Cited by 69 - Related articles - BL Direct - All 4 versions
- ►jbc.org JA Chavez, TA Knotts, LP Wang, G Li, RT … - Journal of Biological Chemistry, 2003 - ASBMB Multiple studies suggest that lipid oversupply to skeletal muscle contributes to
the development of insulin resistance, perhaps by promoting the accumulation of
lipid metabolites capable of inhibiting signal transduction. Herein we ... Cited by 156 - Related articles - BL Direct - All 5 versions
- ►physiology.org A Dobrzyn, J Gorski - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc The sphingomyelin-signaling pathway has been described in many tissues. Ceramide
is the main second messenger in this pathway. Ceramide has also been shown to be
present in skeletal muscles; however, there are few data on the regulation ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MJ Serlie, AJ Meijer, JE Groener, M Duran, E … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Context: Increased plasma free fatty acid (FFA) concentrations may be in part
responsible for the increased levels of ceramide in skeletal muscle of obese
subjects. ... Objective: We studied the effect of lowering and increasing ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►physoc.org JW Helge, A Dobrzyn, B Saltin, J Gorski - Experimental physiology, 2004 - expphysiol.highwire.org In rat skeletal muscle prolonged exercise affects the content and composition of
ceramides, but in human skeletal muscle no data are available on this compound.
Our aim was to examine the content of ceramide- and sphingomyelin fatty ... Cited by 20 - Related articles - BL Direct - All 10 versions
A Dobrzyn, M Zendzian-Piotrowska, J Gorski - J Physiol Pharmacol, 2004 - jpp.krakow.pl The sphingomyelin signalling pathway has been shown to function in different
skeletal muscle types. The aim of the present study was to examine the effect of
endurance training on the functioning of the pathway in the muscles. The ... Cited by 13 - Related articles - Cached - All 6 versions
