WA Banks, AB Coon, SM Robinson, A … - Diabetes, 2004 - Am Diabetes Assoc Obesity is associated with leptin resistance as evidenced by hyperleptinemia.
Resistance arises from impaired leptin transport across the blood-brain barrier
(BBB), defects in leptin receptor signaling, and blockades in downstream ... Cited by 118 - Related articles - BL Direct - All 5 versions
- ►physiology.org WA Banks, CL Farrell - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc Leptin resistance is a major cause of obesity in humans. A major component of
this resistance is likely an impaired transport of leptin across the blood-brain
barrier (BBB). The fattest subgroup of otherwise normal 12-mo-old CD-1 mice ... Cited by 88 - Related articles - BL Direct - All 4 versions
WA Banks - Brain research, 2001 - Elsevier Leptin is a 16 kDa protein secreted by fat cells which regulates body weight and
thermogenesis at sites within the brain. Blood-borne leptin reaches those brain
sites because of a saturable transport system located at the blood–brain ... Cited by 48 - Related articles - All 5 versions
- ►endojournals.org SM Hileman, DD Pierroz, H Masuzaki, C … - Endocrinology, 2002 - Endocrine Soc Leptin deficiency causes obesity in rodents and humans, but circulating levels
of leptin are paradoxically elevated in obesity. The mechanisms underlying this
leptin resistance are unknown, but may involve reduced leptin transport ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►physiology.org WA Banks, CM Clever, CL Farrell - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc Impaired blood-brain barrier transport of leptin into the arcuate nucleus has
been suggested to underlie obesity in humans and outbred aging mice. Here, we
used a brain perfusion method in mice to measure transport rates and ... Cited by 74 - Related articles - BL Direct - All 3 versions
- ►physiology.org BE Levin, AA Dunn-Meynell, WA Banks - … Journal of Physiology- Regulatory, Integrative and …, 2004 - Am Physiological Soc Rats selectively bred to develop diet-induced obesity (DIO) were compared with
those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard
to their central leptin signaling and blood-brain barrier (BBB) transport. ... Cited by 115 - Related articles - BL Direct - All 6 versions
WA Banks - Current pharmaceutical design, 2003 - ingentaconnect.com Abstract: Leptin has emerged as a major regulator of body adiposity. The
majority of humans with obesity have a resistance to leptin. Human and rodent
studies indicate that the major cause of this resistance arises from an ... Cited by 64 - Related articles - BL Direct - All 6 versions
AJ Kastin, V Akerstrom - Neuroendocrinology, 2000 - content.karger.com Since fasting is one of the few factors found to change the rate of entry of
leptin into brain, we used multiple-time regression analysis to study the
effects of pretreatment with glucose or insulin on leptin transport across ... Cited by 33 - Related articles - BL Direct - All 5 versions
AJ Kastin, V Akerstrom - Peptides, 2000 - ncbi.nlm.nih.gov Food deprivation and adrenalectomy are associated with low concentrations of
leptin in blood and the absence of obesity. Because leptin is known to cross the
blood-brain barrier (BBB) by a saturable transport system, we examined ... Cited by 35 - Related articles - All 2 versions
WA Banks, CR DiPalma, CL Farrell - Peptides, 1999 - ncbi.nlm.nih.gov Leptin is a 17-kDa protein secreted by fat cells that regulates body adiposity
by crossing the blood-brain barrier (BBB) to affect feeding and thermogenesis.
Obese human and rodent models of dietary obesity have shown decreased ... Cited by 147 - Related articles - All 3 versions
