- ►diabetesjournals.org T Hansotia, LL Baggio, D Delmeire, SA Hinke, … - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1
(GLP-1) are gut-derived incretins that potentiate glucose clearance following
nutrient ingestion. Elimination of incretin receptor action in GIPR −/− ... Cited by 110 - Related articles - BL Direct - All 13 versions
- ►nih.gov F Preitner, M Ibberson, I Franklin, C Binnert, … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The role of the gluco-incretin hormones GIP and GLP-1 in the control of β cell
function was studied by analyzing mice with inactivation of each of these
hormone receptor genes, or both. Our results demonstrate that glucose ... Cited by 95 - Related articles - BL Direct - All 10 versions
- ►eje-online.org [PDF] MK Reimer, JJ Holst, B Ahren - European Journal of Endocrinology, 2002 - EFES Objectives: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme,
dipeptidyl peptidase IV (DPPIV), are being explored in the treatment of
diabetes. We examined the long-term influence of a selective, orally active ... Cited by 107 - Related articles - BL Direct - All 9 versions
- ►endocrinology-journals.org [PDF] CF Deacon, S Wamberg, P Bie, TE Hughes, JJ … - Journal of Endocrinology, 2002 - Soc Endocrinology The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are degraded by dipeptidyl peptidase IV (DPP
IV), thereby losing insulinotropic activity. DPP IV inhibition reduces ... Cited by 63 - Related articles - BL Direct - All 3 versions
D Marguet, L Baggio, T Kobayashi, AM … - Proceedings of the National Academy of Sciences of …, 2000 - National Acad Sciences A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or
CD26, EC 3.4.14.5), specifically cleave off N-terminal dipeptides from
substrates having proline or alanine in amino acid position 2. This enzyme ... Cited by 280 - Related articles - BL Direct - All 11 versions
SL Conarello, Z Li, J Ronan, RS Roy, L Zhu, … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of
peptidases, is involved in the metabolic inactivation of a glucose-dependent
insulinotropic hormone, glucagon-like peptide 1 (GLP-1), and other incretin ... Cited by 161 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org JA Pospisilik, J Martin, T Doty, JA Ehses, N … - Diabetes, 2003 - Am Diabetes Assoc Recent studies into the physiology of the incretins glucose-dependent
insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have added
stimulation of β-cell growth, differentiation, and cell survival to well- ... Cited by 163 - Related articles - BL Direct - All 4 versions
MA Nauck, A El-Ouaghlidi - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 608–611 DOI 10.1007/s00125-005-1704-8 FOR
DEBATE MA Nauck . A. El-Ouaghlidi The therapeutic actions ... Cited by 45 - Related articles - All 2 versions
T Nagakura, N Yasuda, K Yamazaki, H Ikuta, … - Biochemical and Biophysical Research …, 2001 - Elsevier Glucagon-like peptide-1 (GLP-1) is an incretin, which induces glucose-dependent
insulin secretion. GLP-1 is rapidly degraded by dipeptidyl peptidase IV (DPPIV)
after its release. We investigated whether DPPIV-deficient F344/DuCrj rats ... Cited by 60 - Related articles - BL Direct - All 6 versions
BO Ahrén, E Simonsson, H Larsson, M Landin … - Diabetes Care, 2002 - Am Diabetes Assoc OBJECTIVE—Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment
modality for type 2 diabetes. To circumvent the drawback of the short half-life
of GLP-1, inhibitors of the GLP-1–degrading enzyme dipeptidyl peptidase ... Cited by 276 - Related articles - BL Direct - All 7 versions
