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Scholar Results 1 - 10 of about 101 related to Ye: Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. (0.09 sec) 

Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes


G Ye, NS Metreveli, RV Donthi, S Xia, M Xu, … - Diabetes, 2004 - Am Diabetes Assoc
Many diabetic patients suffer from a cardiomyopathy that cannot be explained by
poor coronary perfusion. Reactive oxygen species (ROS) have been proposed to
contribute to this cardiomyopathy. Consistent with this we found evidence ...
Cited by 61 - Related articles - BL Direct - All 4 versions

Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic …


X Shen, S Zheng, NS Metreveli, PN Epstein - Diabetes, 2006 - Am Diabetes Assoc
We previously reported damage and elevated biogenesis in cardiac mitochondria of
a type 1 diabetic mouse model and proposed that mitochondria are one of the
major targets of oxidative stress. In this study, we targeted ...
Cited by 55 - Related articles - BL Direct - All 5 versions

Overexpression of metallothionein reduces diabetic cardiomyopathy


Q Liang, EC Carlson, RV Donthi, PM Kralik, X … - Diabetes, 2002 - Am Diabetes Assoc
Many diabetic patients suffer from cardiomyopathy, even in the absence of
vascular disease. This diabetic cardiomyopathy predisposes patients to heart
failure and mortality from myocardial infarction. Evidence from animal ...
Cited by 89 - Related articles - BL Direct - All 4 versions

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

- physiology.org
X Shen, S Zheng, V Thongboonkerd, M Xu, WM … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
Diabetic cardiomyopathy is a common complication leading to heightened risk of
heart failure and death. In the present report, we performed proteomic analysis
on total cardiac proteins from the OVE26 mouse model of type 1 diabetes to ...
Cited by 71 - Related articles - BL Direct - All 4 versions

Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice


OJ How, E Aasum, DL Severson, WY Chan, … - Diabetes, 2006 - Am Diabetes Assoc
Altered cardiac metabolism and function (diabetic cardiomyopathy) has been
observed in diabetes. We hypothesize that cardiac efficiency, the ratio of
cardiac work (pressure-volume area [PVA]) and myocardial oxygen consumption ...
Cited by 58 - Related articles - BL Direct - All 5 versions

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob …


PK Mazumder, BT O'Neill, MW Roberts, J … - Diabetes, 2004 - Am Diabetes Assoc
Diabetes alters cardiac substrate metabolism. The cardiac phenotype in
insulin-resistant states has not been comprehensively characterized. The goal of
these studies was to determine whether the hearts of leptin-deficient ...
Cited by 100 - Related articles - BL Direct - All 6 versions

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair …

- ahajournals.org
S Boudina, S Sena, BT O'Neill, P Tathireddy, … - Circulation, 2005 - Am Heart Assoc
Methods and Results— Cardiac function, M O 2 , mitochondrial respiration, and
ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts.
Contractile function and M O 2 in glucose-perfused ob/ob hearts were ...
Cited by 76 - Related articles - All 10 versions

Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive …


G Ye, NS Metreveli, J Ren, PN Epstein - Diabetes, 2003 - Am Diabetes Assoc
Many individuals with diabetes experience impaired cardiac contractility that
cannot be explained by hypertension and atherosclerosis. This cardiomyopathy may
be due to either organ-based damage, such as fibrosis, or to direct damage ...
Cited by 105 - Related articles - BL Direct - All 5 versions

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of …

- endojournals.org
J Buchanan, PK Mazumder, P Hu, G … - Endocrinology, 2005 - Endocrine Soc
Hyperglycemia is associated with altered myocardial substrate use, a condition
that has been hypothesized to contribute to impaired cardiac performance. The
goals of this study were to determine whether changes in cardiac ...
Cited by 69 - Related articles - BL Direct - All 5 versions

Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes


PM Kralik, G Ye, NS Metreveli, X Shen, PN … - Cardiovascular Toxicology, 2005 - Springer
*Author to whom all correspondence and reprint requests should be addressed:
E-mail: paul.epstein@ louisville.eduu. Received: 2/8/05 Revised: 3/28/05
Accepted: 3/29/05 Cardiovascular Toxicology, vol. 5, no. 3, 285–292, 2005
Cited by 14 - Related articles - BL Direct - All 4 versions


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