- ►diabetesjournals.org P Schrauwen, MKC Hesselink - Diabetes, 2004 - Am Diabetes Assoc Recent evidence points toward decreased oxidative capacity and mitochondrial
aberrations as a major contributor to the development of insulin resistance and
type 2 diabetes. In this article we will provide an integrative view on the ... Cited by 160 - Related articles - BL Direct - All 4 versions
P Schrauwen, MKC Hesselink - DIABETES, 2004 - Am Diabetes Assoc Recent evidence points toward decreased oxidative ca- pacity and mitochondrial
aberrations as a major con- tributor to the development of insulin resistance
and type 2 diabetes. In this article we will provide an integrative view on ... Related articles
- ►shouxi.net VB Ritov, EV Menshikova, J He, RE Ferrell, … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of
mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus
lateralis muscle was obtained by percutaneous biopsy from 11 volunteers ... Cited by 194 - Related articles - All 6 versions
- ►unimaas.nl [PDF] P Schrauwen, MKC Hesselink, EE Blaak, LB … - Diabetes, 2001 - Am Diabetes Assoc Recently, a role for uncoupling protein-3 (UCP3) in carbohydrate metabolism and
in type 2 diabetes has been suggested. Mice overexpressing UCP3 in skeletal
muscle showed reduced fasting plasma glucose levels, improved glucose ... Cited by 67 - Related articles - BL Direct - All 6 versions
DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy
production. Because the insulin resistance of skeletal muscle in type 2 diabetes
and obesity entails dysregulation of the oxidation of both carbohydrate and ... Cited by 531 - Related articles - BL Direct - All 4 versions
- ►hug-ge.ch [PDF] AP Russell, G Gastaldi, E Bobbioni-Harsch, P … - FEBS letters, 2003 - Elsevier Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and
endurance-trained (ET) humans and are considered a pathogenic factor in the
development of insulin resistance, in the former. We postulate that this ... Cited by 54 - Related articles - All 8 versions
P Schrauwen - Proceedings of the Nutrition Society, 2007 - Cambridge Univ Press The physiological function of the mitochondrial uncoupling protein (UCP), UCP3,
is still under debate. There is, however, ample evidence to indicate that, in
contrast to UCP1, the primary function of UCP3 is not the dissipation of ... Cited by 44 - Related articles - BL Direct - All 4 versions
- ►unimaas.nl [PDF] J Hoeks, MKC Hesselink, W Sluiter, G … - FEBS letters, 2006 - Elsevier Since the discovery of uncoupling protein-3 (UCP3) in 1997, many studies were
devoted to the function of this UCP1 homologue, which is primarily expressed in
skeletal muscle. However, its physiological role remains to be established. ... Cited by 12 - Related articles - All 12 versions
MKC Hesselink, P Schrauwen - Hormone and metabolic research, 2005 - cat.inist.fr Thyroid hormones have long been known to stimulate energy expenditure partly via
loss of metabolic efficiency. The mechanism underlying the loss in metabolic
efficiency observed, however, is not yet understood. An important candidate ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England journal of medicine, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination
with infusions of [6,6- 2 H 2 ]glucose in healthy, young, lean,
insulin-resistant offspring of patients with type 2 diabetes and insulin- ... Cited by 781 - Related articles - BL Direct - All 14 versions
