- ►diabetesjournals.org HC Chen, M Rao, MP Sajan, M Standaert, Y … - Diabetes, 2004 - Am Diabetes Assoc Mice that lack acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme
in mammalian triglyceride synthesis, have decreased adiposity and increased
insulin sensitivity. Here we show that insulin-stimulated glucose transport ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►physiology.org HC Chen, Z Ladha, SJ Smith, RV Farese Jr - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc Mice lacking acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in
triglyceride synthesis, have increased energy expenditure and therefore are
resistant to obesity. Because ambient temperature can significantly affect ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►nih.gov HC Chen, DR Jensen, HM Myers, RH Eckel, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Recent studies have identified the white adipose tissue (WAT) as an important
endocrine organ that regulates energy and glucose metabolism via a number of
secreted factors. Mice lacking acyl CoA:diacylglycerol acyltransferase 1 ... Cited by 57 - Related articles - BL Direct - All 9 versions
- ►physiology.org RS Streeper, SK Koliwad, CJ Villanueva, RV … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Mice lacking acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), an enzyme that
catalyzes the terminal step in triacylglycerol synthesis, have enhanced insulin
sensitivity and are protected from obesity, a result of increased energy ... Cited by 6 - Related articles - BL Direct - All 7 versions
- ►biologists.org S Cases, P Zhou, JM Shillingford, BS … - Development, 2004 - dev.biologists.org Mammary gland development is a complex process that is dependent on interactions
between the developing mammary epithelium and the surrounding stromal tissues.
We show that mice lacking the triglyceride synthesis enzyme acyl CoA: ... Cited by 15 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org HC Chen, SJ Stone, P Zhou, KK Buhman, RV … - Diabetes, 2002 - Am Diabetes Assoc Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two DGAT
enzymes known to catalyze the final step in mammalian triglyceride synthesis.
Mice deficient in DGAT1 are resistant to obesity and have enhanced insulin ... Cited by 52 - Related articles - BL Direct - All 7 versions
SW Lee, K Kim, MC Rho, MY Chung, YH Kim, … - Planta medica, 2004 - thieme-connect.com Triglycerides represent the major form of stored energy in eukaryotes. But, a
high triglyceride level is known to be a major risk factor for coronary heart
disease, obesity and hypertriglyceridemia [1]. Triglyceride synthesis has ... Cited by 9 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org HC Chen, RV Farese Jr - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc Because the ability to make triglycerides is essential for the accumulation of
adipose tissue, inhibition of triglyceride synthesis may ameliorate obesity and
its related medical consequences. Acyl coenzyme A (CoA):diacylglycerol ... Cited by 44 - Related articles - All 6 versions
- ►endojournals.org MP Sajan, ML Standaert, A Miura, CR Kahn, … - Molecular Endocrinology, 2004 - Endocrine Soc Insulin receptor substrates (IRSs) 1 and 2 are postulated to control the
activation of phosphatidylinositol 3-kinase (PI3K)-dependent signaling factors,
namely, atypical protein kinase C (aPKC) and protein kinase B (PKB)/Akt, ... Cited by 11 - Related articles - BL Direct - All 4 versions
G Zhao, AJ Souers, M Voorbach, HD Falls, B … - Journal of medicinal chemistry, 2008 - ncbi.nlm.nih.gov A highly potent and selective DGAT-1 inhibitor was identified and used in rodent
models of obesity and postprandial chylomicron excursion to validate DGAT-1
inhibition as a novel approach for the treatment of metabolic diseases. ... Cited by 11 - Related articles - All 5 versions
