H Zhou, POT Tran, S Yang, T Zhang, E LeRoy … - Diabetes, 2004 - Am Diabetes Assoc The glucagon response is the first line of defense against hypoglycemia and is
lost in insulin-dependent diabetes. The ß-cell "switch-off" hypothesis proposes
that a sudden cessation of insulin secretion from ß-cells into the portal ... Cited by 39 - Related articles - BL Direct - All 4 versions
KM Hope, POT Tran, H Zhou, E Oseid, E … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell
function during hypoglycemia has not been assessed previously in isolated
islets, largely because they characteristically do not respond to glucose ... Cited by 43 - Related articles - BL Direct - All 4 versions
B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory
response to hypoglycemia states that a decrease in arterial glucose → a
decrease in β-cell insulin secretion → a decrease in tonic α-cell ... Cited by 60 - Related articles - All 6 versions
S Banarer, VP McGregor, PE Cryer - Diabetes, 2002 - Am Diabetes Assoc Because absence of the glucagon response to falling plasma glucose
concentrations plays a key role in the pathogenesis of iatrogenic hypoglycemia
in patients with insulin-deficient diabetes and the mechanism of this ... Cited by 67 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] H Maruyama, A Hisatomi, L Orci, GM Grodsky … - Journal of Clinical Investigation, 1984 - pubmedcentral.nih.gov Abstract. To determine if glucagon secretion is under physiological control of
intra-islet insulin, pan- creata from normal rats were perfused at a 100 mg/dl
glucose concentration with either guinea pig antiinsulin serum or normal ... Cited by 120 - Related articles - All 5 versions
- ►endojournals.org H Zhou, T Zhang, E Oseid, J Harmon, N … - Endocrinology, 2007 - Endocrine Soc The intraislet insulin hypothesis has been proposed to explain absent glucagon
responses to hypoglycemia. Recently we directly confirmed this hypothesis by
restoring glucagon secretion via provision of a pancreatic artery insulin ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still
poorly understood. In particular, the relative importance of direct metabolic
coupling versus paracrine regulation by β-cell secretory products is ... Cited by 66 - Related articles - All 5 versions
S Uehara, A Muroyama, N Echigo, R Morimoto … - Diabetes, 2004 - Am Diabetes Assoc In islets of Langerhans, l-glutamate is stored in glucagon-containing secretory
granules of α-cells and cosecreted with glucagon under low-glucose conditions.
The l-glutamate triggers secretion of γ-aminobutyric acid (GABA) from ... Cited by 25 - Related articles - BL Direct - All 5 versions
I Franklin, J Gromada, A Gjinovci, S … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During
hyperglycemia, glucagon secretion is inhibited by paracrine factors from other
islet cells, but in type 1 and type 2 diabetic patients, this suppression ... Cited by 74 - Related articles - All 4 versions
