KM Hope, POT Tran, H Zhou, E Oseid, E Leroy, RP … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell function during hypoglycemia
has not been assessed previously in isolated islets, largely because they characteristically do
not respond to glucose deprivation by secreting glucagon. We examined this hypothesis ... Cited by 43 - Related articles - BL Direct - All 4 versions
H Zhou, POT Tran, S Yang, T Zhang, E LeRoy, E Oseid, … - Diabetes, 2004 - Am Diabetes Assoc The glucagon response is the first line of defense against hypoglycemia and is lost in
insulin-dependent diabetes. The ß-cell "switch-off" hypothesis proposes that a sudden cessation
of insulin secretion from ß-cells into the portal circulation of the islet during hypoglycemia ... Cited by 39 - Related articles - BL Direct - All 4 versions
B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia
states that a decrease in arterial glucose → a decrease in β-cell insulin secretion → a decrease
in tonic α-cell inhibition by insulin → an increase in α-cell glucagon secretion. To test this ... Cited by 60 - Related articles - All 6 versions
S Banarer, VP McGregor, PE Cryer - Diabetes, 2002 - Am Diabetes Assoc Because absence of the glucagon response to falling plasma glucose concentrations plays a
key role in the pathogenesis of iatrogenic hypoglycemia in patients with insulin-deficient diabetes
and the mechanism of this defect is unknown, and given evidence in experimental ... Cited by 67 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still poorly
understood. In particular, the relative importance of direct metabolic coupling versus paracrine
regulation by β-cell secretory products is unresolved. Here, we compare the responses to ... Cited by 66 - Related articles - All 5 versions
- ►nih.gov [PDF] H Maruyama, A Hisatomi, L Orci, GM … - Journal of Clinical …, 1984 - pubmedcentral.nih.gov Abstract. To determine if glucagon secretion is under physiological control of intra-islet
insulin, pan- creata from normal rats were perfused at a 100 mg/dl glucose concentration with
either guinea pig antiinsulin serum or normal guinea pig serum in a nonrecirculating ... Cited by 120 - Related articles - All 5 versions
- ►jbc.org J Diao, Z Asghar, CB Chan, MB Wheeler - Journal of Biological Chemistry, 2005 - ASBMB The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic
-cells. However, much less is known about the role of the IR in -cells. To assess the role of the
IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org NR Gosmanov, E Szoke, Z Israelian, T Smith, PE … - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—During the 2nd h of the insulin infusion, when somatostatin or saline was no longer
being infused, plasma glucose (∼2.6 mmol/l) and insulin levels (∼570 pmol/l) were comparable
in both sets of experiments (both P > 0.4). In the saline experiments, insulin secretion ... Cited by 27 - Related articles - All 5 versions
[CITATION] Islet-cell secretion determines glucagon release from neighbouring-cells
A Wendt, B Birnir, K Buschard, J Gromada, A Salehi, S … - Diabetes, 2004 - Am Diabetes Assoc Outside the CNS, GABA and GAD, the enzyme catalyzing the formation of the
neurotransmitter, are present at high levels in the pancreatic β-cells (2,3). GAD65 is the most
abundant, if not the only, isoform of GAD in human islets (4) and has been implicated in ... Cited by 84 - Related articles - BL Direct - All 4 versions
