AE Butler, J Jang, T Gurlo, MD Carty, WC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass,
increased β-cell apoptosis, and impaired insulin secretion. Also, islets in
type 2 diabetes often contain deposits of islet amyloid derived from islet ... Cited by 92 - Related articles - BL Direct - All 9 versions
- ►pnas.org [PDF] J Janson, WC Soeller, PC Roche, RT Nelson, … - Proceedings of the National Academy of Sciences, 1996 - National Acad Sciences Proc. Natl. Acad. Sci. USA Vol. 93, pp. 7283-7288, July 1996 Medical Sciences ... Spontaneous diabetes mellitus in transgenic mice expressing human islet
amyloid polypeptide ... JULIETrE JANSON*, WALTER C. SOELLERt, PATRICK C. ... Cited by 135 - Related articles - BL Direct - All 11 versions
RA Ritzel, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by a relative β-cell deficit as a result of
increased β-cell apoptosis and islet amyloid derived from the β-cell peptide
islet amyloid polypeptide (IAPP). Human IAPP (h-IAPP) but not mouse IAPP ... Cited by 73 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and
is preceded by impaired fasting glucose (IFG). The islet anatomy in IFG and type
2 diabetes reveals an ∼50 and 65% deficit in β-cell mass, with increased ... Cited by 39 - Related articles - BL Direct - All 4 versions
AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass.
In contrast, obese humans with type 2 diabetes have an ∼60% deficit in β-cell
mass. Recent studies in rodents reveal that β-cell mass is regulated, ... Cited by 145 - Related articles - BL Direct - All 6 versions
… Höppener, C Oosterwijk, MG Nieuwenhuis, G … - Diabetologia, 1999 - Springer Type II (non-insulin-dependent) diabetes mellitus is a common, age-related,
multifactorial disease [1, 2]. Although still debated, it seems that the primary
de- fect in most subjects developing Type II diabetes in- volves resistance ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►endojournals.org RL Hull, GT Westermark, P Westermark, SE … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these
deposits contain the unique amyloidogenic peptide islet amyloid polypeptide.
Autopsy studies in humans have demonstrated that islet amyloid is ... Cited by 118 - Related articles - BL Direct - All 6 versions
J Janson, RH Ashley, D Harrison, S McIntyre, … - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc NIDDM is characterized by islet amyloid deposits and decreased -cell mass. Islet
amyloid is derived from the locally expressed protein islet amyloid polypeptide
(IAPP). While it is now widely accepted that abnormal aggregation of IAPP ... Cited by 227 - Related articles - BL Direct - All 7 versions
B Konarkowska, JF Aitken, J Kistler, S Zhang … - FEBS J, 2006 - interscience.wiley.com Human amylin is a small fibrillogenic protein that is the major constituent of
pancreatic islet amyloid, which occurs in most subjects with type 2 diabetes.
There is evidence that it can elicit in vitro apoptosis in islet β-cells, ... Cited by 34 - Related articles - BL Direct - All 4 versions
M Couce, LA Kane, TD O'Brien, J Charlesworth … - Diabetes, 1996 - Am Diabetes Assoc Islet amyloid derived from islet amyloid polypeptide (IAPP) is a well-recognized
feature of type II diabetes. However, the mechanism of islet amyloidogenesis is
unknown. In vitro studies suggest that amino acid residues 20-29 in human, ... Cited by 56 - Related articles - BL Direct - All 4 versions
