- ►diabetesjournals.org RN Kulkarni, MG Roper, G Dahlgren, DQ Shih, LM … - Diabetes, 2004 - Am Diabetes Assoc Mice with deletion of insulin receptor substrate (IRS)-1 (IRS-1 knockout [KO] mice) show mild
insulin resistance and defective glucose-stimulated insulin secretion and reduced insulin synthesis.
To further define the role of IRS-1 ... Cited by 66 - Related articles - BL Direct - All 4 versions
PD Borge, BA Wolf - Journal of Biological Chemistry, 2003 - ASBMB We have previously characterized an insulin receptor substrate 1 (IRS-1)-overexpressing β-cell
line. These β-cells demonstrated elevated fractional insulin secretion and elevated cytosolic Ca 2+
levels compared with wild-type and ... Cited by 20 - Related articles - BL Direct - All 4 versions
GG Xu, ZY Gao, PD Borge Jr, PA Jegier, RA Young, BA … - Biochemistry, 2000 - ncbi.nlm.nih.gov The insulin receptor signaling pathway is present in beta-cells and is believed to be important in
beta-cell function. We show here that insulin directly regulates beta-cell function in isolated
rodent islets. Long-term insulin ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►physiology.org AM Hennige, U Ozcan, T Okada, US Jhala … - American Journal of …, 2005 - Am Physiological Soc Insulin and IGF-I activate antiapoptotic pathways via insulin receptor substrate (IRS) proteins in
most mammalian cells, including -cells. IRS-1 knockout (IRS-1KO) mice show growth retardation,
hyperinsulinemia, and hyperplastic ... Cited by 25 - Related articles - BL Direct - All 6 versions
T Minuth, J Thömmes, MR Kula - Biotechnology and Applied …, 1996 - 万方数据资源系统 Cholesterol oxidase was isolated from Nocardia rhodochrous and purified on a bench scale to produce
an analytical-grade enzyme preparation, The integral membrane protein was solubilized using a mixed
nonionic polyoxyethylene surfactant solution and selectively extracted after temperature-induced phase ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org MG Roper, W Qian, BB Zhang, RN Kulkarni, CR Kahn, … - Diabetes, 2002 - Am Diabetes Assoc L-783,281, an antidiabetic fungal metabolite that has previously been shown to activate insulin
signaling in CHO cells, was tested for its effect on intracellular Ca 2+ ([Ca 2+ ] i ) and insulin
secretion in single mouse ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►googlepages.com [PDF] A Varadi, L Lebel, Y Hashim, Z Mehta, SJH Ashcroft, R … - Diabetologia, 1999 - Springer Genetic factors play an important part in the patho- genesis of Type II (non-insulin-dependent)
diabetes mellitus, a heterogeneous disorder characterised by defects in insulin action as well as
insulin secretion [1]. ... Cited by 36 - Related articles - BL Direct - All 6 versions
M Ohsugi, C Cras-Meneur, Y Zhou, E Bernal- … - Journal of Biological …, 2005 - ASBMB Running Title: Multiple roles of insulin signaling in islet cells ... Reduced Expression of the
Insulin Receptor in Mouse Insulinoma (MIN6) Cells Reveals Multiple Roles of Insulin Signaling in
Gene Expression, Proliferation, ... Cited by 39 - Related articles - All 5 versions
- ►nih.gov [PDF] A Varadi, E Molnar, CG Ostenson, SJ … - Biochemical …, 1996 - pubmedcentral.nih.gov Glucose-dependent sequestration of Ca#+ into endoplasmic retic- ulum and its subsequent release play
an important role in the control of intracellular Ca#+ concentration, which regulates insulin
secretion in pancreatic β-cells. ... Cited by 70 - Related articles - BL Direct - All 5 versions
