P Holm, B Rydlander, H Luthman, I Kockum - Diabetes, 2004 - Am Diabetes Assoc We have previously reported suggestive linkage to chromosome 5p13-q13 in type 1 diabetic
families. ISL1, a transcription factor involved in pancreas development, maps to this region. Sequencing
of the ISL1 gene in patients and control subjects identified seven single nucleotide ... Cited by 23 - Related articles - BL Direct - All 4 versions
A Biason-Lauber, B Boehm, M Lang-Muritano, BR … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 900–905 DOI 10.1007/s00125-005-1723-5 ARTICLE A.
Biason-Lauber . B. Boehm . M. Lang-Muritano . BR Gauthier . T. Brun . CB Wollheim . EJ
Schoenle Association of childhood type 1 diabetes mellitus with a variant ... Cited by 30 - Related articles - All 4 versions
Y Shimajiri, M Shimabukuro, T Tomoyose, H Yogi, I … - … and Biophysical Research …, 2003 - Elsevier We previously reported that a missense mutation at codon 121 (CGG Arg to TGG Trp ,
R121W) of PAX4 may be associated with the onset of type 2 diabetes in Japanese. In this
study, we determined the frequency of the R121W mutation of PAX4 and characterized ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org Y Shimajiri, T Sanke, H Furuta, T Hanabusa, T … - Diabetes, 2001 - Am Diabetes Assoc Pax4 is one of the transcription factors that play an important role in the differentiation of islet
β-cells. We scanned the Pax4 gene in 200 unrelated Japanese type 2 diabetic patients and found
a missense mutation (R121W) in 6 heterozygous patients and 1 homozygous patient ( ... Cited by 45 - Related articles - BL Direct - All 4 versions
A Kanatsuka, Y Tokuyama, O Nozaki, K Matsui, T … - Metabolism, 2002 - Elsevier Polymorphisms in [beta ]-cell transcription factor genes, Ala45Thr in the NeuroD1 gene and Arg121Trp
in the Pax4 gene, have been reported. To clarify the role of these mutations in the pathogenesis
of late-onset diabetes, we examined the insulin secretion and sensitivity in diabetic ... Cited by 20 - Related articles - BL Direct - All 3 versions
Y Ueda - FEBS letters, 2000 - Elsevier Activin A, a member of the TGFβ superfamily, has many physiological and developmental
functions. In pancreatic β cell cultures, activin promotes cell differentiation and insulin
production. The author has found activin increases gene expression of the PAX4, one of ... Cited by 24 - Related articles - All 9 versions
T Miyamoto, T Kakizawa, K Ichikawa, S Nishio, S … - … and Biophysical Research …, 2001 - Elsevier The paired-homeodomain transcription factor PAX4 is expressed in the early pancreas, but is
later restricted to β cells and not expressed in mature islets, suggesting an important role of PAX4
in differentiation and development of pancreatic islet. Here we show that PAX4 mRNA ... Cited by 14 - Related articles - BL Direct - All 3 versions
R Hermann, J Mantere, K Lipponen, R Veijola, G … - Diabetes, 2005 - Am Diabetes Assoc We aimed to assess the possible contribution of the PAX4 transcription factor gene to the genetic
background of type 1 diabetes. We analyzed four coding polymorphisms of the PAX4 gene in
498 cases with type 1 diabetes and 825 control subjects from Finland and Hungary. All ... Cited by 5 - Related articles - BL Direct - All 6 versions
Y Li, H Nagai, T Ohno, H Ohashi, T Murohara, H Saito, … - Leukemia research, 2006 - Elsevier The PAX4 gene, a member of the paired box (PAX) gene family, is thought to be involved in regulating
the fate of β-cells in the mammalian pancreas. We observed the aberrant expression of PAX4
mRNA in 10 of 15 hematologic cell lines analyzed by RT-PCR. The restoration of PAX4 ... Cited by 5 - Related articles - All 5 versions
Y Tokuyama, K Matsui, T Ishizuka, T Egashira, A … - Metabolism, 2006 - Elsevier Mutations in PAX4, a transcription factor involved in the beta-cell differentiation, could predispose
to the development of type 2 diabetes mellitus. To clarify the role of PAX4 Arg121Trp mutation
on the development of type 2 diabetes mellitus, we try to determine the clinical phenotype ... Cited by 6 - Related articles - All 3 versions
