B Xu, SQ Hu, YC Chu, S Wang, R Wang, SH … - Diabetes, 2004 - Am Diabetes Assoc Mutations in human insulin cause an autosomal-dominant syndrome of diabetes and fasting
hyperinsulinemia. We demonstrate by residue-specific photo cross-linking that diabetes-associated
mutations occur at receptor-binding sites. The studies use para-azido-phenylalanine, ... Cited by 16 - Related articles - BL Direct - All 5 versions
B Xu, SQ Hu, YC Chu, K Huang, SH Nakagawa, J … - Biochemistry, 2004 - pubs.acs.org Because you do not have JavaScript enabled, the Quick Search functionality is not displayed
here. Please enable JavaScript or use the Advanced Search Page. ... This work was supported
in part by the Diabetes Research & Training Center at the University of Chicago (SHN) ... Cited by 28 - Related articles - BL Direct - All 3 versions
B Xu, Q Hua, SH Nakagawa, W Jia, YC Chu, PG … - Journal of molecular …, 2002 - Elsevier The hydrophobic core of vertebrate insulins contains an invariant isoleucine residue at position
A2. Lack of variation may reflect this side-chain's dual contribution to structure and function: Ile
A2 is proposed both to stabilize the A1-A8 α-helix and to contribute to a “hidden” ... Cited by 28 - Related articles - BL Direct - All 6 versions
Q Hua, S Nakagawa, SQ Hu, W Jia, S Wang, MA … - Journal of Biological …, 2006 - ASBMB How insulin binds to the insulin receptor has long been a subject of speculation. Although the
structure of the free hormone has been extensively characterized, a variety of evidence suggests
that a conformational change occurs upon receptor binding. Here, we employ chiral ... Cited by 16 - Related articles - All 11 versions
- ►jbc.org SH Nakagawa, Q Hua, SQ Hu, W Jia, S Wang, PG … - Journal of Biological …, 2006 - ASBMB Insulin contains a -turn (residues B20-B23) interposed between two receptor-binding
elements, the central -helix of the B chain (B9-B19) and its C-terminal -strand (B24-B28). The
turn contains conserved glycines at B20 and B23. Although insulin exhibits marked ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►jbc.org MA Weiss, QX Hua, W Jia, SH Nakagawa, YC Chu, … - Journal of Biological …, 2001 - ASBMB Previous studies have demonstrated that the potency and thermodynamic stability of human
insulin are enhanced in concert by substitution of Thr A8 by arginine or histidine. These surface
substitutions stabilize the N-terminal -helix of the A chain, a key element of hormone- ... Cited by 21 - Related articles - BL Direct - All 3 versions
K Huang, B Xu, SQ Hu, YC Chu, Q Hua, Y Qu, B Li, … - Journal of molecular …, 2004 - Elsevier Binding of insulin to the insulin receptor plays a central role in the hormonal control of
metabolism. Here, we investigate possible contact sites between the receptor and the conserved
non-polar surface of the B-chain. Evidence is presented that two contiguous sites in an α- ... Cited by 35 - Related articles - All 3 versions
ZL Wan, K Huang, B Xu, SQ Hu, S Wang, YC Chu, PG … - Biochemistry, 2005 - 万方数据资源系统 Naturally occurring mutations in insulin associated with diabetes mellitus identify critical determinants
of its biological activity. Here, we describe the crystal structure of insulin Wakayama, a clinical
variant in which a conserved valine in the Achain (residue A3) is substituted by leucine. ... Cited by 31 - Related articles - All 6 versions
SH Nakagawa, M Zhao, QX Hua, SQ Hu, ZL Wan, W … - Biochemistry, 2005 - 万方数据资源系统 How insulin binds to its receptor is unknown despite decades of investigation. Here, we employ
chiral mutagenesis-comparison of corresponding D and L amino acid substitutions in the
hormone-to define a structural switch between folding-competent andactive ... Cited by 23 - Related articles - All 5 versions
