K Maedler, J Størling, J Sturis, RA Zuellig … - Diabetes, 2004 - Am Diabetes Assoc Increasing evidence indicates that a progressive decrease in the functional
β-cell mass is the hallmark of both type 1 and type 2 diabetes. The underlying
causes, β-cell apoptosis and impaired secretory function, seem to be ... Cited by 36 - Related articles - All 3 versions
K Maedler, J Storling, J Sturis, RA Zuellig … - DIABETES-NEW YORK-., 2004 - AMERICAN DIABETES ASSOCIATION INC Cited by 29 - Related articles - BL Direct
POG Arkhammar, T Mandrup-Poulsen, MY … - DIABETES, 2004 - Am Diabetes Assoc Increasing evidence indicates that a progressive de- crease in the functional
-cell mass is the hallmark of both type 1 and type 2 diabetes. The underlying
causes, -cell apoptosis and impaired secretory function, seem to be partly ... Related articles - All 2 versions
- ►endojournals.org RA Ritzel, JB Hansen, JD Veldhuis, PC Butler - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc In health, most insulin is secreted in pulses. Type 2 diabetes mellitus (TTDM)
is characterized by impaired pulsatile insulin secretion with a defect in
insulin pulse mass. It has been suggested that this defect is partly due to ... Cited by 35 - Related articles - BL Direct - All 5 versions
M Guldstrand, V Grill, A Björklund, PE Lins, … - Diabetes & metabolism, 2002 - cat.inist.fr Objectif: Notre but était de distinguer les effets bénéfiques de la mise au
repos des cellules bêta des autres effets de la correction de l'hyperglycémie.
Pour cela nous avons utilisé le diazoxide qui bloque de façon réversible ... Cited by 40 - Related articles - BL Direct - All 3 versions
K Skak, CF Gotfredsen, D Lundsgaard, JB … - Diabetes, 2004 - Am Diabetes Assoc Treatment with ATP-sensitive K + channel openers (KCOs) leads to inhibition of
insulin secretion and metabolic “rest” in β-cells. It is hypothesized that
in type 1 diabetes this may reduce β-cell death resulting from metabolic ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►endojournals.org K Maedler, RD Carr, D Bosco, RA Zuellig, T … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Loss of ß-cell mass and function raises a concern regarding the application of
sulfonylureas for the treatment of type 2 diabetes because previous studies have
shown that agents that cause closure of inwardly rectifying K + ... Cited by 77 - Related articles - All 6 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D Konrad … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin
demand such as obesity. Failure to adapt leads to diabetes. The molecular
mechanisms controlling this adaptive process are unclear. Fas is a death ... Cited by 20 - Related articles - BL Direct - All 11 versions
K Maedler, P Sergeev, JA Ehses, Z Mathe, D … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to
impaired β cell function and apoptosis in human pancreatic islets. IL-1
receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1β ... Cited by 82 - Related articles - BL Direct - All 13 versions
JB Hansen, GA PO, TB Bodvarsdottir, P Wahl - Current Medicinal Chemistry, 2004 - ingentaconnect.com Abstract: The pattern of insulin release is crucial for regulation of glucose
and lipid haemostasis. Deficient insulin release causes hyperglycemia and
diabetes, whereas excessive insulin release can give rise to serious ... Cited by 25 - Related articles - BL Direct - All 2 versions
