- ►diabetesjournals.org A Duttaroy, CL Zimliki, D Gautam, Y Cui, D Mears, J … - Diabetes, 2004 - Am Diabetes Assoc Pancreatic muscarinic acetylcholine receptors play an important role in stimulating insulin and
glucagon secretion from islet cells. To study the potential role of the M 3 muscarinic receptor
subtype in cholinergic stimulation of insulin release, we initially examined the effect of the ... Cited by 47 - Related articles - BL Direct - All 4 versions
WS Zawalich, KC Zawalich, GJ Tesz, MM Taketo, J … - … and Biophysical Research …, 2004 - Elsevier The impact of muscarinic type 3 receptor knockout (M 3 KO) on the cholinergic regulation of insulin
secretion and phospholipase C (PLC) activation was determined. Islets isolated from control,
wild-type mice or heterozygotes responded with comparable insulin secretory responses ... Cited by 13 - Related articles - All 5 versions
- ►endojournals.org P Gilon, JC Henquin - Endocrine reviews, 2001 - Endocrine Soc Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by intrapancreatic
nerve endings during the preabsorptive and absorptive phases of feeding. In ß-cells, ACh binds
to muscarinic M 3 receptors and exerts complex effects, which culminate in an increase of ... Cited by 162 - Related articles - BL Direct - All 5 versions
SH Tang, GW Sharp - Diabetes, 1997 - Am Diabetes Assoc Carbachol can stimulate insulin release in RINm5F cells by a mechanism that does not involve
the elevation of cytosolic free Ca2+ concentrations or the activation of conventional protein kinase
Cs (Mol Pharmacol 47:863-870, 1995). Thus, a novel signal transduction pathway links ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] TP Iismaa, EA Kerr, JR Wilson, L Carpenter, N Sims, TJ … - Diabetes, 2000 - Am Diabetes Assoc Expression of muscarinic receptors in rat islets, RINm5F cells, and INS-1 cells was established
by reverse transcriptase–polymerase chain reaction (RT-PCR) and quanti fied by RNase
protection. Both methods indicated that m3 and m1 receptors were expressed approxi- ... Cited by 38 - Related articles - BL Direct - All 3 versions
D Gautam, SJ Han, FF Hamdan, J Jeon, B Li, JH Li, Y … - Cell Metabolism, 2006 - Elsevier One of the hallmarks of type 2 diabetes is that pancreatic β cells fail to release sufficient amounts
of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated by
many hormones and neurotransmitters including acetylcholine, the major ... Cited by 28 - Related articles - All 11 versions
AC Boschero, M Szpak-Glasman, EM … - American Journal of …, 1995 - Am Physiological Soc Page 1. Oxotremorine-m potentiation of glucose-induced insulin release from rat islets
involves MS muscarinic receptors AC BOSCHERO, M. SZPAK-GLASMAN, EM
CARNEIRO, S. BORDIN, I. PAUL, E. ROJAS, AND I. ATWATER ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] RB Barlow, LS McMillen, MA Veale - British journal of …, 1991 - pubmedcentral.nih.gov Page 1. Br. J. Pharmacol. (1991), 102, 657-662 The use of 4-diphenylacetoxy-N-(2-chloroethyl)-
piperidine (4-DAMP mustard) for estimating the apparent affinities of some agonists acting at
muscarinic receptors in guinea-pig ileum 'RB Barlow, Louise S. McMillen & MA Veale ... Cited by 16 - Related articles - All 4 versions
- ►diabetesjournals.org DE Johnson, H Yamazaki, KM Ward, AW Schmidt, WS … - Diabetes, 2005 - Am Diabetes Assoc Treatment with the atypical antipsychotics olanzapine and clozapine has been associated with
an increased risk for deterioration of glucose homeostasis, leading to hyperglycemia,
ketoacidosis, and diabetes, in some cases independent of weight gain. Because these ... Cited by 31 - Related articles - All 6 versions
- ►diabetesjournals.org Y Guo, M Traurig, L Ma, S Kobes, I Harper, AM Infante, … - Diabetes, 2006 - Am Diabetes Assoc The muscarinic acetylcholine receptor subtype M3 (CHRM3) gene is expressed in islet β-cells
and has a role in stimulating insulin secretion; therefore, CHRM3 was analyzed as a candidate
gene for type 2 diabetes in Pima Indians. Ten variants were genotyped in a family-based ... Cited by 7 - Related articles - BL Direct - All 5 versions
