- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier, BE … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in hormone-sensitive
lipase-null mice (HSL −/− ), both in vivo and in vitro. The focus of the current study was to gain
further insight into the signaling role and regulation of lipolysis in islet tissue. The effect of ... Cited by 34 - Related articles - BL Direct - All 6 versions
H Mulder, S Yang, MS Winzell, C Holm, B Ahrén - Diabetes, 2004 - Am Diabetes Assoc Lipids may serve as coupling factors in K ATP -independent glucose sensing in β-cells. We have
previously demonstrated that β-cells harbor lipase activities, one of which is the hormone-sensitive
lipase. Whether β-cell lipases are critical for glucose-stimulated insulin secretion (GSIS) ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Fex, CS Olofsson, U Fransson, K Bacos, H Lindvall, … - Endocrinology, 2004 - Endocrine Soc Lipids are thought to serve as coupling factors in insulin secretion. Hormone-sensitive lipase
(HSL) is expressed in pancreatic ß-cells and could potentially regulate insulin secretion via mobilization
of stored triglycerides. Here, we examined the impact of HSL deficiency on fuel ... Cited by 19 - Related articles - BL Direct - All 4 versions
P Masiello, M Novelli, M Bombara, V Fierabracci, S … - Metabolism, 2002 - Elsevier This study intended to test the hypothesis that intracellular lipolysis in the pancreatic [beta ] cells
is implicated in the regulation of insulin secretion stimulated by nutrient secretagogues or cyclic
adenosine monophosphate (cAMP) agonists. Indeed, although lipid signaling molecules ... Cited by 26 - Related articles - BL Direct - All 7 versions
H Lindvall, P Nevsten, K Ström, R Wallenberg, F … - Journal of Biological …, 2004 - ASBMB Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization in many cell types.
Two isoforms of HSL are known to date, namely HSL adi (84 kDa in rat) and HSL tes (130 kDa
in rat). These are encoded by the same gene, with exons 1-9 encoding the parts that are ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Roduit, P Masiello, SP Wang, H Li, GA Mitchell, M … - Diabetes, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the β-cell adapts
its secretory capacity in obesity and diabetes. In addition, hormone-sensitive lipase (HSL) is
expressed in β-cells and may provide fatty acids necessary for the generation of coupling ... Cited by 74 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SP Wang, S Chung, K Soni, H Bourdages, L Hermo, J … - Endocrinology, 2004 - Endocrine Soc Hormone-sensitive lipase (HSL, Lipe, EC3.1.1.3) is a multifunctional fatty acyl esterase that is
essential for male fertility and spermatogenesis and that also plays important roles in the function
of adipocytes, pancreatic ß-cells, and adrenal cortical cells. Gene-targeted HSL-deficient ( ... Cited by 12 - Related articles - BL Direct - All 4 versions
H Mulder, M Sörhede-Winzell, JA Contreras, M Fex, … - Journal of Biological …, 2003 - ASBMB Lipid metabolism plays an important role in glucose homeostasis under normal and pathological
conditions. In adipocytes, skeletal muscle, and pancreatic β-cells, lipids are mobilized from acylglycerides
by the hormone-sensitive lipase (HSL). Here, the consequences of a targeted disruption ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►physiology.org L Hu, JT Deeney, CJ Nolan, ML Peyot, A … - American Journal of …, 2005 - Am Physiological Soc Intracellular lipolysis is a major pathway of lipid metabolism that has roles, not only in the provision
of free fatty acids as energy substrate, but also in intracellular signal transduction. The latter is
likely to be particularly important in the regulation of insulin secretion from islet -cells. The ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] BA Cunningham, AMT Richard, JS Dillon, JT … - Biochemical …, 2003 - pubmedcentral.nih.gov Glucose-induced insulin secretion from isolated, perifused rat islets is pulsatile with a period
of about 5–10 min, similar to the insulin oscillations that are seen in healthy humans but which
are impaired in Type II diabetes. We evaluated the pattern of enhancement by the potent ... Cited by 24 - Related articles - BL Direct - All 7 versions
